[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545916":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":50,"locations":59,"responsibleParty":85,"collaborators":88,"id":99,"slug":25,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":100,"sex":106,"minAge":107,"maxAge":25,"enrollmentInfo":108,"targetDuration":25,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":25,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Xinqiao Hospital of Chongqing","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Endovascular thrombectomy","EXPERIMENTAL","Patients in this group will be treated with medical management plus endovascular thrombectomy",[13,14],"Drug: Medical management","Procedure: Endovascular thrombectomy",{"label":16,"type":17,"description":18,"interventionNames":19},"Medical management","ACTIVE_COMPARATOR","Patients in this group will be treated with medical management alone",[13],[21,26],{"type":22,"name":16,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Medical management includes IV thrombolysis, antiplatelet, and\u002For anticoagulation.",[9,16],null,{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":25},"PROCEDURE","Endovascular thrombectomy with stent-retriever, local aspiration, angioplasty, and\u002For stenting.",[9],[31,35,38,41,44,47],{"name":32,"affiliation":33,"role":34},"Guangxiong Yuan","Xiangtan Central Hospital","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":37,"role":34},"Congguo Yin","Hangzhou First Hospital of Zhejiang University",{"name":39,"affiliation":40,"role":34},"Tingyu Yi","Zhangzhou Affiliated Hospital of Fujian Medical University",{"name":42,"affiliation":43,"role":34},"Chong Zheng","Longyan First Hospital of Fujian Medical University",{"name":45,"affiliation":46,"role":34},"Chenghua Xu","Taizhou First People's Hospital",{"name":48,"affiliation":49,"role":34},"Zhongfan Ruan","The First Affiliated Hospital, Hengyang Medical School, University of South China",[51,55],{"name":48,"role":52,"phone":53,"phoneExt":25,"email":54},"CONTACT","15616320002","ruanzhongfan@sina.com",{"name":56,"role":52,"phone":57,"phoneExt":25,"email":58},"Zhongming Qiu","13236599269","qiuzhongmingdoctor@163.com",[60,73],{"facility":49,"status":61,"city":62,"state":63,"zip":25,"country":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"RECRUITING","Hengyang","Hunan","China",{"type":66,"coordinates":67},"Point",[68,69],112.61888,26.88946,{"lat":69,"lon":68},[72],{"name":48,"role":52,"phone":25,"phoneExt":25,"email":54},{"facility":33,"status":61,"city":74,"state":63,"zip":75,"country":64,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Xiangtan","421001",{"type":66,"coordinates":77},[78,79],112.9,27.85,{"lat":79,"lon":78},[82],{"name":32,"role":52,"phone":83,"phoneExt":25,"email":84},"18973223018","yuanguangxiong74@163.com",{"type":86,"investigatorFullName":56,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Professor",[89,91,92,95,97,98],{"name":90,"class":6},"The First Affiliated Hospital of University of South China",{"name":33,"class":6},{"name":93,"class":94},"Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University","UNKNOWN",{"name":96,"class":94},"Longyan First Affiliated Hospital of Fujian Medical University",{"name":46,"class":6},{"name":40,"class":6},"100545916",false,"NCT06388148","Endovascular Treatment for eXtra-Large Ischemic Stroke","Efficacy and Safety of Endovascular Thrombectomy Plus Medical Management Versus Medical Management Alone in Acute Ischemic Stroke Patients With Large Vessel Occlusion and Extra-Large Infarct Core: A Multicenter, Randomized Controlled Trial","XL STROKE-2","Inclusion Criteria:\n\n1. Age 18 years or older, and modified Rankin scale score = 0 or 1 in patients 80 years or older;\n2. Acute ischemic stroke within 6 hours from last known well to randomization, or with negative MRI-FLAIR (no change on FLAIR sequence and presence of infarct on MRI-DWI) if \\> 6 hours or unknown last known well time;\n3. Occlusion of the internal carotid artery, M1 or M2 segment of the middle cerebral artery confirmed by CTA\u002FMRA\u002FDSA;\n4. Baseline ASPECTS score of 0-2 or infarct core volume ≥100ml;\n5. The patient or patient's representative signs a written informed consent form.\n\nExclusion Criteria:\n\n1. CT or MR evidence of hemorrhage;\n2. Evidence of mass effect with ventricular effacement, midline shift or herniation on baseline imaging;\n3. Vessel tortuosity where it is expected that the thrombectomy device will not be able to reach the occlusion site or result in unstable access;\n4. History of bleeding disorders, severe heart, liver or kidney disease, or sepsis;\n5. Currently participating in another investigational drug study;\n6. Any terminal illness with life expectancy less than 6 months.","ALL","18 Years",{"count":109,"type":110},286,"ESTIMATED","INTERVENTIONAL",[113],"NA","The role of endovascular thrombectomy in patients with extra-large ischemic burden is still unclear. The XL STROKE-2 randomized trial is aiming to investigate the efficacy and safety of mechanical thrombectomy in acute extra-large ischemic stroke patients with large vessel occlusion.",[116],"Stroke, Acute Ischemic","2025-12-18",{"date":119,"type":120},"2025-12-26","ACTUAL",{"date":122,"type":120},"2024-06-16",{"date":124,"type":110},"2027-01-31",{"name":56,"class":6},2]