About this trial

The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared to treatment as usual. However, no studies to date have assessed their effectiveness when used in combination. In light of this knowledge gap, the primary objective of this study will be to test the effectiveness of PE augmented with CRP as compared to PE with care as usual (self-guided treatment plan), an active comparator, for the reduction of suicide ideations and attempts for individuals with comorbid PTSD.

Eligibility criteria

Qualifiers

Current diagnosis of PTSD or subthreshold PTSD; ability to speak and understand the English language; and ability to complete the informed consent process.

Disqualifiers

Substance use disorder requiring medical management; imminent suicide risk warranting inpatient hospitalization or suicide-focused treatment; and impaired mental status that precludes the ability to provide informed consent (e.g., intoxication, psychosis, mania).

Trial design

Treatments tested in this trial

  • Prolonged exposure

Treatment groups

100 Participants
are divided into 2 treatment groups

Locations

1
The Ohio State University43210, ColumbusOhio, United States

Sponsors and collaborators

Ohio State University

Lead sponsor

United States Department of Defense

Collaborator

Congressionally Directed Medical Research Programs

Collaborator