[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540896":3},{"organization":4,"outcomesModule":7,"designInfo":53,"detailedDescription":59,"studyPopulation":52,"armGroups":60,"interventions":73,"overallOfficials":52,"centralContacts":83,"locations":90,"responsibleParty":110,"collaborators":52,"id":112,"slug":52,"hasResults":113,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":52,"eligibilityCriteria":117,"healthyVolunteers":113,"sex":118,"minAge":119,"maxAge":52,"enrollmentInfo":120,"targetDuration":52,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":92,"whyStopped":52,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},{"fullName":5,"class":6},"Taichung Veterans General Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":52},[9],{"measure":10,"description":11,"timeFrame":12},"48hr opioid consumption","The primary outcome of this study was the total oral morphine equivalent (OME) dose received within 48 hours after surgery. OME was calculated using a conversion toolkit within our hospital's electronic medical record system, which standardizes opioid analgesic doses to oral morphine equivalents according to established guidelines","Day 2",[14,18,20,23,25,28,30,33,36,40,44,48],{"measure":15,"description":16,"timeFrame":17},"Postoperative static pain scores-Day 1","Pain score reported by patients when resting","Day 1",{"measure":19,"description":16,"timeFrame":12},"Postoperative static pain scores-Day 2",{"measure":21,"description":22,"timeFrame":17},"Postoperative dynamic pain scores-Day 1","Pain score reported by patients when mobilizing or deep coughing",{"measure":24,"description":22,"timeFrame":12},"Postoperative dynamic pain scores-Day 2",{"measure":26,"description":27,"timeFrame":17},"postoperative incentive spirometry volume (ml)-Day 1","daily volume of incentive spirometry",{"measure":29,"description":27,"timeFrame":12},"postoperative incentive spirometry volume (ml)-Day 2",{"measure":31,"description":27,"timeFrame":32},"postoperative incentive spirometry volume (ml)-Day 3","Day 3",{"measure":34,"description":35,"timeFrame":32},"QoL15 (POD3)","quality of life questionnaire (QoL15) at postoperative day 3",{"measure":37,"description":38,"timeFrame":39},"Serum cytokine (IL-6, IL-8, IL-10) - baseline","Baseline serum inflammatory cytokine, collected from the arterial line and the central venous line after induction of general anesthesia","During surgery (at the time the induction phase was completed, patients were under general anesthesia, and both arterial line and central venous line were in place)",{"measure":41,"description":42,"timeFrame":43},"Serum cytokine (IL-6, IL-8, IL-10)- aortic declamp","Serum inflammatory cytokines were collected after the aorta was declamped from both the arterial and central venous lines.","Within 10 min after the aortic declamping",{"measure":45,"description":46,"timeFrame":47},"Serum cytokine (IL-6, IL-8, IL-10)- 6hrs after aortic decalmped","Serum inflammatory cytokines were collected 6 hours after the aorta was declamped from both the arterial and central venous lines.","6 hours after the aorta was declamped",{"measure":49,"description":50,"timeFrame":51},"Serum cytokine (IL-6, IL-8, IL-10)-24 hrs after surgery","Serum levels of inflammatory cytokines were collected 24 hours after surgery from both the arterial and central venous lines.","24 hours after the surgery",null,{"allocation":54,"interventionModel":55,"interventionModelDescription":52,"primaryPurpose":56,"observationalModel":52,"timePerspective":52,"maskingInfo":57},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":58,"maskingDescription":52,"whoMasked":52},"NONE","Regional nerve blocks, including Pecto-intercostal block (PIFB) and Erector spinae plane block (ESPB), can provide a certain level of analgesia for thoracic and cardiac surgeries. This study focuses on patients undergoing their first conventional sternotomy for cardiac surgery. They are randomly assigned to receive either PIFB or ESPB for pain relief. Comparisons are made between the two groups for postoperative 48-hour analgesic medication requirements, static and dynamic postoperative pain scores, improvements in postoperative respiratory function, quality of life index (QoL15), and other clinically relevant prognostic indicators.",[61,67],{"label":62,"type":63,"description":64,"interventionNames":65},"Group E","EXPERIMENTAL","Patients who receive erector spinae plane block(ESPB) before cardiac surgery",[66],"Procedure: Erector spinae plane block (ESPB)",{"label":68,"type":69,"description":70,"interventionNames":71},"Group P","ACTIVE_COMPARATOR","Patients who receive Pecto-intercostal plane block(PIFB) before cardiac surgery",[72],"Procedure: Pecto-intercostal fascial plane blok (PIFB)",[74,79],{"type":75,"name":76,"description":77,"armGroupLabels":78,"otherNames":52},"PROCEDURE","Erector spinae plane block (ESPB)","Bilateral ESP: 0.5% ropivacaine 0.3 ml per kg (ideal body weight) each side, 30 min before skin excision. After surgery, use pump to deliver an intermittent automatic bolus of 0.3 ml per kg 0.16% ropivacaine every 4 hours each side.",[62],{"type":75,"name":80,"description":81,"armGroupLabels":82,"otherNames":52},"Pecto-intercostal fascial plane blok (PIFB)","Bilateral PIFB: 0.5% ropivacaine 0.3 ml per kg (ideal body weight) each side, 30 min before skin excision. After surgery, use pump to deliver an intermittent automatic bolus of 0.3 ml per kg 0.16% ropivacaine every 4 hours each side.",[68],[84],{"name":85,"role":86,"phone":87,"phoneExt":88,"email":89},"Yi-Ting Chang, Dr.","CONTACT","(+886)4-23592525","4101","taco@vghtc.gov.tw",[91],{"facility":5,"status":92,"city":93,"state":94,"zip":95,"country":94,"countryCode":96,"cosmosGeoPoint":97,"geoPoint":102,"contacts":103},"RECRUITING","Taichung","Taiwan","407","TW",{"type":98,"coordinates":99},"Point",[100,101],120.6839,24.1469,{"lat":101,"lon":100},[104,106,108],{"name":105,"role":86,"phone":87,"phoneExt":88,"email":89},"Yi-Ting Chang, MD",{"name":107,"role":86,"phone":87,"phoneExt":88,"email":89},"Yi-Ting Chang",{"name":105,"role":109,"phone":52,"phoneExt":52,"email":52},"PRINCIPAL_INVESTIGATOR",{"type":109,"investigatorFullName":107,"investigatorTitle":111,"investigatorAffiliation":5,"oldNameTitle":52,"oldOrganization":52},"Attending Anesthesiologist","100540896",false,"NCT06322810","ESP Versus PIFB for Analgesia in Open Cardiac Surgery: a Randomized Control Trial","Comparison of Erector Spiane Plan Block (ESPB) Versus Pecto-intercostal Fascial Block(PIFB) for Analgesia and Respiratory Function Recovery in Cardiac Surgery: a Randomized Control Trial","Inclusion Criteria:\n\n* Adults patients, elective and first-time cardiac surgery patients undergoing traditional sternotomy. Procedures include coronary artery bypass surgery, valve repair or replacement surgery, atrial and ventricular septal defect repair surgery, and other open-heart surgeries.\n\nExclusion Criteria:\n\n* 1\\. Emergency surgery 2. Anticipated combined major aortic vascular surgery 3. Already admitted to the ICU or on a ventilator before surgery.","ALL","18 Years",{"count":121,"type":122},80,"ESTIMATED","INTERVENTIONAL",[125],"NA","This clinical trial compares analgesia efficiency and recovery outcomes between two different fascial plane block techniques (ESPB vs.PIFB) in cardiac surgery patients participant population\u002Fhealth conditions\\].\n\nThe main questions it aims to answer are:\n\n* Does ESPB provide superior analgesia than PIFB\n* Do patients who receive ESPB have better recovery outcomes",[128],"Analgesia",[130,131,132],"Erector spinae plane block","Pecto-intercostal plane block","Cardiac surgery","2026-02-22",{"date":135,"type":136},"2026-02-24","ACTUAL",{"date":138,"type":136},"2024-11-08",{"date":140,"type":122},"2026-12-31",{"name":5,"class":6},1]