[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635242":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":57,"id":61,"slug":26,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":86,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Reading","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ETAS® (1500mg)","EXPERIMENTAL","Subjects will consume 1500mg ETAS®\u002Fday (capsule).",[13],"Dietary Supplement: ETAS®",{"label":15,"type":16,"description":17,"interventionNames":18},"Matched placebo","PLACEBO_COMPARATOR","Subjects will consume a matched placebo capsule.",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","ETAS®","1500mg ETAS®",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Matched placebo capsule",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Piril Hepsomali, PhD","CONTACT","+44 118 378 5818","p.hepsomali@reading.ac.uk",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of Reading, School of Psychology and Clinical Languages","RECRUITING","Reading","Berkshire","RG6 6ES","United Kingdom",{"type":46,"coordinates":47},"Point",[48,49],-0.97113,51.45625,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Piril Hepsomali","Principle Investigator",[58],{"name":59,"class":60},"Amino Up Chemicals Co., Ltd.","INDUSTRY","100635242",false,"NCT07550140","ETASCAN Project: ETAS Project 2","The Impact of Chronic Consumption of ETAS® for 12 Weeks on Cognitive, Affective, and Neural Outcomes: A Randomised Parallel Group Placebo-controlled Study","ETASCAN","Inclusion Criteria:\n\n* Aging between 60-80 years old\n* Having normal vision and hearing\n* Having a body mass index between 18.5 and 30\n* Having mild to moderate subjective cognitive complaints\n\nExclusion Criteria:\n\n* Smoking\n* Having food allergies\n* Following restrictive and\u002For unbalanced diets (Appendix 6: Are you vegetarian or vegan? Yes \u002F No; Are you currently on a weight-reducing or other special diet? Yes\u002FNo If 'Yes', please give details.)\n* Being diagnosed with any psychiatric or neurologic conditions (e.g. schizophrenia, depression, dementia) including eating disorders\n* Being diagnosed with any cardiometabolic diseases (including type II diabetes and cardiovascular disease), or hypertension or thrombosis related disorders or suffer from thyroid disease\n* Currently taking anticoagulants, antiplatelet medication, antidepressants, proton-pump inhibitors\n* Currently consuming prebiotic or probiotic supplements\n* Continuous antibiotic use for \\> 3 days within 1 month prior to enrolment\n* Continuous use of weight-loss drug for \\> 1 month before screening\n* Having a significant gastrointestinal (GI) condition affecting absorption including (but not limited to) inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end stage renal disease; active cancer, or treatment for any cancer, in last 3 years\n* History of claustrophobia\n* Fitted with a pacemaker or artificial heart valve\n* Have active implants, such as cochlear, ocular, or penile implant\n* Experience of metal fragments e.g. shrapnel in your eyes or any other part of your body\n* Drug infusion pump installed\n* Have any surgically implanted metal in any part of your body, other than dental fillings and crowns (e.g. joint replacement or bone re-construction)\n* Have had any surgery that might have involved metal implants\n* Current or historical experience of epilepsy\n* Have stimulators for nerves, brain or bone installed\n* Have an intrauterine contraceptive device installed (IUD)\n* Wear transdermal patches containing metal\n* Wear a filling, crown, dental post (entirely within the tooth) associated with root canal treatment, retainer, bridge or braces\n* For scanning, would need to remove coloured contact lenses, nail polish and makeup.\n* Hearing aid wearer\n* Body piercings that you cannot or will not remove for the scanning session\n* Have tattoos or permanent makeup",true,"ALL","60 Years","80 Years",{"count":73,"type":74},60,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.",[80,81,82,83,84,85],"Cognition","Affect (Mental Function)","Sleep","MRI","fMRI","Magnetic Resonance Spectroscopy",[87,88,89,90,91,92,23,93,94,95,96],"grey matter","brain structure","brain function","neurochemistry","executive function","language","depression","anxiety","sleep","gut microbiome","2026-04-17",{"date":99,"type":100},"2026-04-24","ACTUAL",{"date":102,"type":74},"2026-05-05",{"date":104,"type":74},"2027-12-31",{"name":5,"class":6},1]