[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645298":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":69,"collaborators":71,"id":81,"slug":26,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":26,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":26,"enrollmentInfo":89,"targetDuration":26,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":54,"whyStopped":26,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"I.M. Sechenov First Moscow State Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Comprehensive Etiological Diagnosis Group","EXPERIMENTAL","Patients receive standard diagnostics plus molecular test results (PCR, PCR with sequencing) to guide etiotropic therapy",[13],"Diagnostic Test: Molecular tests (PCR, sequencing)",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Clinical Practice Group","ACTIVE_COMPARATOR","Patients receive standard care; molecular test results are blinded for the treating physician",[19],"Diagnostic Test: Standard Clinical Practice",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIAGNOSTIC_TEST","Molecular tests (PCR, sequencing)","PCR and PCR with consequent sequencing of the blood (or tissue) will be performed in addition to the cultural methods in the experimental study arm",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Clinical Practice","Patients receive standard care with analysis of microorganisms in at least 2 or more separate blood culture sets and from cardiac tissue (if surgical treatment is performed); molecular test results are blinded for the treating physician",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Svetlana Rachina, Professor","CONTACT","+7 910 715-89-55","rachina_s_a@staff.sechenov.ru",[38,52,61],{"facility":39,"status":40,"city":41,"state":26,"zip":26,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health","NOT_YET_RECRUITING","Moscow","Russia",{"type":44,"coordinates":45},"Point",[46,47],37.61781,55.75204,{"lat":47,"lon":46},[50],{"name":51,"role":34,"phone":26,"phoneExt":26,"email":26},"Dmitry Popov, Prof",{"facility":53,"status":54,"city":41,"state":26,"zip":26,"country":42,"cosmosGeoPoint":55,"geoPoint":57,"contacts":58},"City Clinical Hospital Named After S. S. Yudin","RECRUITING",{"type":44,"coordinates":56},[46,47],{"lat":47,"lon":46},[59],{"name":60,"role":34,"phone":35,"phoneExt":26,"email":36},"Svetlana Rachina",{"facility":62,"status":54,"city":41,"state":26,"zip":26,"country":42,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"City Clinical Hospital №67 Named After L. A. Vorokhobova",{"type":44,"coordinates":64},[46,47],{"lat":47,"lon":46},[67],{"name":68,"role":34,"phone":26,"phoneExt":26,"email":26},"Svetlana Mirzakhamidova, Dr",{"type":70,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[72,75,77,79],{"name":73,"class":74},"Federal State Budgetary Institution of the Central Research Institute of Epidemiology of Rospotrebnadzor","UNKNOWN",{"name":76,"class":74},"City Clinical Hospital Named After S. S. Yudin, Moscow, Russian Federation",{"name":78,"class":74},"City Clinical Hospital №67 Named After L. A. Vorokhobova, Moscow, Russian Federation",{"name":80,"class":74},"A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health, Moscow, Russian Federation","100645298",false,"NCT07682389","Etiologic Diagnosis Algorithm in Infective Endocarditis","Development and Validation of An Algorithm of Etiological Diagnosis of Infective Endocarditis in Adults: An Open-Label Multicenter Randomized Clinical Trial","Inclusion Criteria:\n\n* Informed consent,\n* Age ≥ 18,\n* IE (definite or possible per the 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis)\n\nExclusion Criteria:\n\n* Pregnancy\u002Fbreastfeeding\n* Unconfirmed or rejected IE diagnosis,\n* Very high risk of death within 14 days due to severe complications of the main or concomitant disease(s), according to the physician's opinion;\n* Prior use of antibiotic therapy (except documented treatment failure).","ALL","18 Years",{"count":90,"type":91},128,"ESTIMATED","INTERVENTIONAL",[94],"NA","The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis",[97,98],"Infective Endocarditis","Microbiology",[100,101,102,103,104],"Infective endocarditis","PCR","Antibiotic therapy","Etiological diagnosis","Sequencing","2026-06-28",{"date":107,"type":108},"2026-07-02","ACTUAL",{"date":110,"type":108},"2026-01-20",{"date":112,"type":91},"2027-02-20",{"name":5,"class":6},3]