[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538689":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":56,"id":60,"slug":25,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Virginia Polytechnic Institute and State University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"eTMS","EXPERIMENTAL","The active side of a TMS coil will be used to administer eTMS application.",[13],"Device: Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"eTMS sham","SHAM_COMPARATOR","The sham side of a TMS coil will be used to administer a sham dosage of eTMS application.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)","EEG is utilized to determine a personalized frequency to then apply TMS to the frontal lobe.",[9,15],null,[27],{"name":28,"affiliation":5,"role":29},"Wynn Legon, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Jessica Florig, MPH","CONTACT","540-526-2261","jnw@vtc.vt.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Fralin Biomedical Research Institute","RECRUITING","Roanoke","Virginia","24016","United States",{"type":45,"coordinates":46},"Point",[47,48],-79.94143,37.27097,{"lat":48,"lon":47},[51,52],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":28,"role":29,"phone":25,"phoneExt":25,"email":25},{"type":29,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Wynn Legon","Assistant Professor",[57],{"name":58,"class":59},"Wave Neuroscience","INDUSTRY","100538689",false,"NCT06294106","eTMS for Veterans and First Responders With PTSD","Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD)","Inclusion Criteria:\n\n* Veteran or first responder\n* diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above\n\nExclusion Criteria:\n\n* Claustrophobia\n* Contraindications to MRI\n* Pregnant\n* Uncontrolled medical, psychological, or neurological conditions\n* Unable to calculate EEG alpha frequency\n* History of ECT or rTMS\n* History of intracranial lesion or increased intracranial pressure\n* History of stroke\n* History of other neurologic conditions\n* Family history of epilepsy\n* Personal history of epilepsy\n* certain medications","ALL","18 Years","65 Years",{"count":70,"type":71},20,"ESTIMATED","INTERVENTIONAL",[74],"NA","A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.",[77],"Post Traumatic Stress Disorder","2026-06-30",{"date":80,"type":81},"2026-07-02","ACTUAL",{"date":83,"type":81},"2024-06-10",{"date":85,"type":71},"2028-09",{"name":5,"class":6},1]