[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645084":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":63,"collaborators":65,"id":67,"slug":32,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":32,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":32,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":94,"whyStopped":32,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Nutraland USA, Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AppleX™ Group","EXPERIMENTAL","100 mg whole-apple extract capsule standardized to 15% fisetin, taken once daily with breakfast for 24 weeks.",[13],"Dietary Supplement: Apple Extract",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","An identical look-alike microcrystalline cellulose capsule, taken once daily with breakfast for 24 weeks",[19],"Other: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Apple Extract","A whole-apple extract standardized to 15% fisetin within a natural polyphenol matrix of quercetin, chlorogenic acid, and procyanidins. Administered as a 100 mg capsule taken orally once daily with breakfast for 24 weeks.",[9],[27],"AppleX™",{"type":29,"name":15,"description":30,"armGroupLabels":31,"otherNames":32},"OTHER","An identical, matching inactive look-alike capsule containing microcrystalline cellulose. Administered orally once daily with breakfast for 24 weeks.",[15],null,[34],{"name":35,"affiliation":36,"role":37},"Dr. Bill Clark, PhD","Natprologix, LLC","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":32,"email":43},"Dr. Bill Clark, Ph.D.","CONTACT","727-365-3420","drbill@natprologix.com",{"name":45,"role":41,"phone":46,"phoneExt":32,"email":47},"Alethios, Inc.","650-206-8006","support@alethios.com",[49],{"facility":45,"status":32,"city":50,"state":51,"zip":52,"country":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"San Francisco","California","94109","United States",{"type":55,"coordinates":56},"Point",[57,58],-122.41942,37.77493,{"lat":58,"lon":57},[61],{"name":62,"role":41,"phone":46,"phoneExt":32,"email":47},"Zeenia Framroze, BA MPhil",{"type":64,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[66],{"name":45,"class":6},"100645084",false,"NCT07678346","Evaluation of AppleX™ Apple Extract on Anti-Inflammatory and Healthy Aging Effects","A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Anti-Inflammatory and Healthy Aging Effects of AppleX™ Apple Extract (15% Fisetin) in Adults 45-70 Years of Age","Inclusion Criteria:\n\n* Age 45-70 years at time of enrollment\n* Meets questionnaire-based inflammatory enrichment criteria (at least 2 of 5 risk factors, per Section 4.2)\n* Non-smoker (no tobacco or nicotine use within 6 months of enrollment)\n* Willing and able to maintain stable diet, exercise habits, and supplement use throughout the 24-week study period\n* No major medication changes planned during the study period\n* Willing to perform home-based DBS collections at T0, T12, and T24\n* Access to a smartphone or computer to complete eConsent and online questionnaires\n* Able to provide informed consent via the Alethios eConsent platform\n\nExclusion Criteria:\n\n* Current use of prescription anti-inflammatory medications including NSAIDs (regular use ≥3x\u002Fweek), corticosteroids, or DMARDs\n* Diagnosis of an autoimmune or inflammatory disease (e.g., rheumatoid arthritis, lupus, IBD, multiple sclerosis)\n* Active or unstable cardiovascular disease requiring medication changes during the study period\n* History of cancer within the past 5 years (except non-melanoma skin cancer)\n* Regular use of supplemental fisetin, quercetin, or resveratrol within 30 days of enrollment\n* Pregnancy, breastfeeding, or planning to become pregnant during the study\n* Known allergy to apple or apple-derived products\n* Body mass index (BMI) \\>40 kg\u002Fm²",true,"ALL","45 Years","70 Years",{"count":78,"type":79},70,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this clinical trial is to learn if AppleX™ Apple Extract can help lower systemic inflammation in adults aged 45-70 with signs of low-grade inflammation. It will also look at the extract's effects on fatigue, joint comfort, and biological aging metrics.\n\nThe main questions it aims to answer are:\n\n* Does taking AppleX™ Apple Extract daily lower high-sensitivity C-reactive protein (hsCRP) levels, a key marker of inflammation in the blood?\n* Does AppleX™ Apple Extract improve participant-reported fatigue and joint comfort?\n* Does the extract slow down biological or epigenetic aging metrics compared to a placebo?\n\nResearchers will compare AppleX™ Apple Extract to a placebo (a look-alike capsule that contains no active ingredients) to see if the apple extract has a measurable anti-inflammatory and healthy aging effect.",[85,86,87,88],"Systemic Inflammation (hsCRP)","Healthy Aging","Vitality","Healthy Adult Participants",[90,91,92,93],"Apple extract","Fisetin","Flavonoids","polyphenols","NOT_YET_RECRUITING","2026-06-25",{"date":97,"type":98},"2026-07-01","ACTUAL",{"date":100,"type":79},"2026-07",{"date":102,"type":79},"2027-02",{"name":5,"class":6},1]