[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100456880":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":38,"centralContacts":30,"locations":42,"responsibleParty":62,"collaborators":64,"id":68,"slug":30,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":30,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":30,"enrollmentInfo":76,"targetDuration":30,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":30,"overallStatus":44,"whyStopped":30,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"City of Hope Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diagnostic (needle biopsy, DDMS-2)","EXPERIMENTAL","Patients undergo needle biopsy for collection of tissue samples. Tissue samples are analyzed using DDMS-2. Patients' medical records are also reviewed.",[13,14,15],"Procedure: Diagnostic Procedure","Other: Electronic Health Record Review","Procedure: Needle Biopsy",[17,26,31],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","Diagnostic Procedure","Analysis via DDMS-2",[9],[23,24,25],"Diagnostic Method","Diagnostic Technique","Diagnostic Test",{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Electronic Health Record Review","Review of medical records",[9],null,{"type":18,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Needle Biopsy","Undergo needle biopsy",[9],[36,37],"Aspiration Biopsy","Puncture Biopsy",[39],{"name":40,"affiliation":5,"role":41},"John H Yim","PRINCIPAL_INVESTIGATOR",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Duarte","California","91010","United States",{"type":50,"coordinates":51},"Point",[52,53],-117.97729,34.13945,{"lat":53,"lon":52},[56,61],{"name":57,"role":58,"phone":59,"phoneExt":30,"email":60},"John H. Yim","CONTACT","626-218-3590","JYim@coh.org",{"name":57,"role":41,"phone":30,"phoneExt":30,"email":30},{"type":63,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR",[65],{"name":66,"class":67},"National Cancer Institute (NCI)","NIH","100456880",false,"NCT05229341","Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules","Evaluation of DNA Methylation Signatures in Diagnosis and Management of Thyroid Nodules","Inclusion Criteria:\n\n* Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis\n* Over the age of 18\n* Any gender, race and ethnicity\n* Patients must provide informed consent prior to use of their tissues and clinical data\n\nExclusion Criteria:\n\n* Children are excluded from the study, since the biology of children thyroid nodules is different from adults","ALL","18 Years",{"count":77,"type":78},1450,"ESTIMATED","INTERVENTIONAL",[81],"NA","This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.",[84],"Thyroid Gland Carcinoma","2026-02-20",{"date":87,"type":88},"2026-02-23","ACTUAL",{"date":90,"type":88},"2021-10-22",{"date":92,"type":78},"2026-10-22",{"name":5,"class":6},1]