[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602332":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":28,"studyPopulation":29,"armGroups":30,"interventions":44,"overallOfficials":50,"centralContacts":55,"locations":65,"responsibleParty":75,"collaborators":78,"id":82,"slug":19,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":19,"maxAge":19,"enrollmentInfo":91,"targetDuration":19,"studyType":94,"phases":19,"briefSummary":95,"conditions":96,"keywords":19,"overallStatus":68,"whyStopped":19,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Liaquat University of Medical & Health Sciences","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":20},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"salivary cytology","A method will be developed for evaluation of detection of oral cancer","1 year",{"measure":14,"description":15,"timeFrame":12},"evaluation of telomere length of salivary cells","Telomere length will be evaluation in the saliva of three groups",{"measure":17,"description":18,"timeFrame":12},"evaluation of biochemicals of saliva","saliva of three groups will be compared on the basis of salivary enzymes",null,[21],{"measure":22,"description":23,"timeFrame":24},"A scoring system will be developed for the screening of patients at risk of oral submucous fibrosis","A scoring system will be developed including cytology, genetic and biochemistry and algorithm will be designed for accurate assessment of the oral cancer","2 years",{"allocation":19,"interventionModel":19,"interventionModelDescription":19,"primaryPurpose":19,"observationalModel":26,"timePerspective":27,"maskingInfo":19},"CASE_CONTROL","CROSS_SECTIONAL","The project aims to evaluate salivary cytology, genes and biochemistry of the healthy normal population and compare it with that of the oral submucous fibrosis and oral cancer. For salivary experiments 3 cc of fresh saliva will be collected and analysed.","The three groups will be recruited: healthy volunteers with unremarkable oral examination, patients with oral submucous fibrosis regardless of mouth opening and biopsy proven oral cancer patients.",[31,36,40],{"label":32,"type":19,"description":33,"interventionNames":34},"Normal healthy volunteers","oral examination will be done, those without any oral infection, oral submucous fibrosis or cancer will be included in health volunteer group",[35],"Diagnostic Test: saliva a a diagnostic tool for early detection of oral cancer",{"label":37,"type":19,"description":38,"interventionNames":39},"oral submucous fibrosis","Patients with oral submucous fibrosis both with and without limited mouth opening",[35],{"label":41,"type":19,"description":42,"interventionNames":43},"oral cancer patients","patients with biopsy proven oral cancer",[35],[45],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":19},"DIAGNOSTIC_TEST","saliva a a diagnostic tool for early detection of oral cancer","Three groups will be compared on the basis of cytology, genes and biochemical analysis",[32,41,37],[51],{"name":52,"affiliation":53,"role":54},"Binafsha Manzoor Prof. Syed, PhD","Liaquat University of Medical and Health Sciences","PRINCIPAL_INVESTIGATOR",[56,61],{"name":57,"role":58,"phone":59,"phoneExt":19,"email":60},"Binafsha Manzoor Prof, SYed, PhD","CONTACT","00923332749201","binafsha.syed@lumhs.edu.pk",{"name":62,"role":58,"phone":63,"phoneExt":19,"email":64},"Fasiha Dr Shah, PhD","00923363019144","fasiha.shah@lumhs.edu.pk",[66],{"facility":67,"status":68,"city":69,"state":70,"zip":19,"country":71,"countryCode":72,"cosmosGeoPoint":19,"geoPoint":19,"contacts":73},"Medical Research Center","RECRUITING","Jāmshoro","Sinch","Pakistan","PK",[74],{"name":52,"role":58,"phone":59,"phoneExt":19,"email":60},{"type":54,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Prof. Binafsha Manzoor Syed","Professor",[79],{"name":80,"class":81},"Sindh Higher Education Commission","UNKNOWN","100602332",false,"NCT07122128","EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)","Saliva as Early Detection Tool for Oral Cancer","Sal","Inclusion Criteria:\n\n* healthy volunteers\n* patients with oral submucous fibrosis\n* patients with biopsy proven oral cancer\n\nExclusion Criteria:\n\n* patients with oral infection",true,"ALL",{"count":92,"type":93},1000,"ESTIMATED","OBSERVATIONAL","Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing.\n\nPatients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.",[97],"The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer","2025-08-07",{"date":100,"type":101},"2025-08-14","ACTUAL",{"date":103,"type":101},"2021-06-01",{"date":105,"type":93},"2026-06-30",{"name":5,"class":6},1]