[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589372":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":13,"interventions":19,"overallOfficials":13,"centralContacts":24,"locations":13,"responsibleParty":30,"collaborators":13,"id":34,"slug":13,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":13,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":13,"studyType":47,"phases":13,"briefSummary":48,"conditions":49,"keywords":51,"overallStatus":53,"whyStopped":13,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":13},{"fullName":5,"class":6},"Al-Mustansiriyah University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Salivary-free amino acid analysis","Unstimulated saliva collection for salivary free amino acids analysis","Baseline :unstimulated saliva collection for salivary glycine , proline , lysine and alanine measurement",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"CASE_CONTROL","CROSS_SECTIONAL","80 healthy children (8-10 years old) will be recruited from primary schools of Baghdad city\u002F Iraq, will be classified according to their level of caries activity (high caries activity, n = 40; negative caries activity, n = 40). Total stimulated and unstimulated saliva will be collected to estimate the caries activity by using the Snyder test, and Amino acid analysis of the saliva will be performed by reversed phase - high performance liquid chromatography (RP-HPLC), respectively.","Children in both genders in 8-10 years old",[20],{"type":21,"name":22,"description":23,"armGroupLabels":13,"otherNames":13},"DIAGNOSTIC_TEST","To compare the effect of salivary glycine , proline , lysine and alanine concentration between participants with high caries activity and participants with negative caries activity","The investigators will measure Salivary-free amino acids by using reverse phase high performance liquid chromatography",[25],{"name":26,"role":27,"phone":28,"phoneExt":13,"email":29},"Abeer Ibrahim Mohammed, B.D.S","CONTACT","+9647709497799","abeeribrahim93@uomustansiriyah.edu.iq",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Abeer Ibrahim Mohammed","Princible investigator","100589372",false,"NCT06953557","Evaluation of the Salivary-free Amino Acids Levels (Glycine , Proline , Lysine , and Alanine ) With Caries Activity","Evaluation of the Salivary-free Amino Acids Levels With Caries Activity","Inclusion Criteria:\n\n* Children aged (8,9,10) years with different caries\n* Absence of signs of gingivitis or periodontal disease.\n\nExclusion Criteria:\n\n* Children out the range of age\n* Children with any systemic discases.\n* Children with appliances in the mouth.\n* Children with appliances in the mouth.\n* Children with antibiotic treatment or any other drug over the last two weeks. B",true,"ALL","8 Years","10 Years",{"count":45,"type":46},80,"ESTIMATED","OBSERVATIONAL","This study will be aimed to investigated the correlation between levels of salivary amino acids (glycine , proline , lysine , alanine ) in the saliva of healthy children with and without active carious lesions and to estimate the predictive capacity of caries susceptibility",[50],"Dental Caries",[52],"Salivary -free amino acid measurment","NOT_YET_RECRUITING","2025-04-23",{"date":56,"type":57},"2025-05-01","ACTUAL",{"date":59,"type":46},"2025-04-30",{"date":61,"type":46},"2025-06-30",{"name":5,"class":6}]