[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596608":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":28,"studyPopulation":29,"armGroups":25,"interventions":30,"overallOfficials":25,"centralContacts":34,"locations":45,"responsibleParty":62,"collaborators":25,"id":66,"slug":25,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":25,"briefSummary":80,"conditions":81,"keywords":25,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Central Hospital, Nancy, France","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"Ex vivo evaluation of the binding of experimental radiolabeled ligands on human tissue by autohistoradiography","Signal \u002Fbackground noise ration, in region of interest","10 days",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"Identify specific tissue fixation profiles according to the nature of the molecules (Antibodies, peptides, nanobodies, etc.).","Signal\u002Fbackground noise ratio (calculated between the target area and a healthy area on the same slice).","1 day",{"measure":19,"description":20,"timeFrame":12},"Compare the biodistribution of the molecule of interest between different types of tissues (tumor, inflammatory, healthy, etc.).","Analysis of biodistribution across the entire section (depending on the nature of the tissue).",{"measure":22,"description":23,"timeFrame":24},"Identify ligands exhibiting specific and relevant tissue binding, warranting further in vivo evaluation.","Inter-tissue differences (tumor, inflammatory, healthy tissue, etc.) for the same molecule.","1 year",null,{"allocation":25,"interventionModel":25,"interventionModelDescription":25,"primaryPurpose":25,"observationalModel":6,"timePerspective":27,"maskingInfo":25},"RETROSPECTIVE","The development of radioligands targeting structures of diagnostic or therapeutic interest is a central challenge in nuclear medicine. However, their selection still relies primarily on animal models, which are poorly representative of human tissue, limiting clinical transposability and delaying innovation, in contradiction with the ethical principles of animal experimentation.\n\nRecent work has highlighted the value of ex vivo approaches on human tissue to better anticipate the specificity of radioligand binding, while reducing the need for animal models. Autohistoradiography, in particular, allows precise visualization of the tissue distribution of radiolabeled molecules, without systemic interference.\n\nThe HERO project aims to structure an ex vivo screening platform, based on anonymized human tissues, to early assess the tissue fixation of experimental ligands in an ethical, translational approach that complies with the principles of the 3Rs (Replacement, Reduction, Refinement).","A maximum of 300 human tissue samples will be analyzed over a period of 5 years.\n\nThis volume allows for the exploration of a variety of tissue types (tumor, inflammatory, healthy) and the testing of several types of radiolabeled molecules, while ensuring adequate reproducibility for each experimental condition.\n\nThe samples will be provided by the Pathology Department of the Nancy University Hospital, in compliance with regulatory and ethical procedures.\n\nEach sample will undergo one or more ex vivo autohistoradiography analyses, without the need for any new samples.",[31],{"type":6,"name":32,"description":33,"armGroupLabels":25,"otherNames":25},"Early assessment of tissue uptake of experimental ligands","Ex vivo evaluation of the binding of experimental radiolabeled ligands on human tissue using autohistoradiography",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Caroline BOURSIER, MD","CONTACT","(0)383154039","+33","c.boursier@chru-nancy.fr",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"Véronique ROCH, MSc","0383154276","v.roch@chru-nancy.fr",[46],{"facility":47,"status":48,"city":49,"state":25,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Chru Nancy","RECRUITING","Vandœuvre-lès-Nancy","54511","France","FR",{"type":54,"coordinates":55},"Point",[56,57],6.17114,48.66115,{"lat":57,"lon":56},[60],{"name":61,"role":37,"phone":43,"phoneExt":25,"email":44},"Veronique Roch, MSc",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","BOURSIER Caroline","Principal Investigator","100596608",false,"NCT07047677","Ex Vivo Evaluation on Human Tissue of the Binding of Experimental Radiolabeled Ligands","Ex Vivo Evaluation of Experimental Radiolabeled Ligand Binding in Human Tissue Using Autohistoradiography HERO (Human Ex-vivo RadiOligand) Platform","HERO","Inclusion Criteria:\n\n* Patients who underwent surgical resection at the Nancy University Hospital after 2019 (Information provided in the welcome booklet or on posters displayed in waiting rooms, mentioning the possible use of data or resection specimens, unless otherwise stated).\n* No documented objection, in accordance with the MR004 methodology.\n* Frozen human tissues (slides, blocks, or sections) from surgical resection or biopsy, transmitted by the CRB or the biopathology department.\n* Samples are fully anonymized before being made available for analysis.\n\nExclusion Criteria:\n\n* • Unusable tissue (degraded, insufficient, contaminated, poorly preserved).\n\n  * Lack of traceability of the material.\n  * Explicit opposition from the patient to the use of their tissue for research.","ALL","18 Years","99 Years",{"count":77,"type":78},300,"ESTIMATED","OBSERVATIONAL","The HERO project aims to structure an ex vivo screening platform, based on anonymized human tissues, to early assess the tissue fixation of experimental ligands in an ethical, translational approach that complies with the principles of the 3Rs (Replacement, Reduction, Refinement).",[82],"Tissue Model","2026-06-03",{"date":85,"type":86},"2026-06-04","ACTUAL",{"date":88,"type":86},"2025-11-01",{"date":90,"type":78},"2030-09-01",{"name":5,"class":6},1]