[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100424854":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":59,"collaborators":24,"id":61,"slug":24,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":24,"overallStatus":43,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise","EXPERIMENTAL","This exercise prescription represents a common or \"conventional\" form of physical activity (e.g., moderate\u002Fbrisk walking). If assigned to this group, participants will perform 45 minutes of moderate intensity continuous steady-state exercise at 70% maximal heart rate (HRmax) to expend 250 calories 4 days per week.",[13],"Behavioral: Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"No exercise","Subjects assigned to this group are to remain sedentary (no planned physical exercise) throughout the duration of the study.",[18],"Behavioral: No exercise",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Participants will complete a moderate intensity continuous exercise 4 days\u002Fweek.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":28},"Participants will remain sedentary throughout the duration of the study.",[15],[29],"Control group",[31],{"name":32,"affiliation":33,"role":34},"Jeffrey F Horowitz, PhD","University of Michigan, School of Kinesiology","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":24,"email":40},"Suzette Howton","CONTACT","734-647-9850","smlstudies@umich.edu",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Ann Arbor","Michigan","48109","United States",{"type":49,"coordinates":50},"Point",[51,52],-83.74088,42.27756,{"lat":52,"lon":51},[55],{"name":56,"role":38,"phone":57,"phoneExt":24,"email":58},"Jeffrey F Horowitz","7346471076","jeffhoro@umich.edu",{"type":34,"investigatorFullName":56,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"professor of Movement Science and director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology","100424854",false,"NCT04812314","Exercise Effects on Adipose Tissue Structure and Function","LG","Inclusion Criteria:\n\n* Age: 18-40\n* Body Mass Index: 27-45 kg\u002Fm2\n* No regularly planned exercise\u002Fphysical activity for at least 6 months\n* Women must have regularly occurring menses and must be premenopausal\n\nExclusion Criteria:\n\n* Evidence\u002Fhistory of cardiovascular or metabolic disease\n* Medications known to affect lipid or glucose metabolism, or inflammation\n* Weight instability ≥ ± 6 pounds in the last 3 months\n* Tobacco or e-cigarette users\n* Women must not be pregnant or actively lactating","ALL","18 Years","40 Years",{"count":71,"type":72},46,"ESTIMATED","INTERVENTIONAL",[75],"NA","Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.",[78,79,80,81,82,83],"Obesity","Metabolic Syndrome","Metabolic Disease","Insulin Resistance","Weight Loss","Weight Gain","2026-06-02",{"date":86,"type":87},"2026-06-04","ACTUAL",{"date":89,"type":87},"2021-03-01",{"date":91,"type":72},"2030-03-01",{"name":5,"class":6},1]