[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498840":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":20,"responsibleParty":40,"collaborators":10,"id":42,"slug":10,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":10,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":10,"overallStatus":22,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"National Heart Centre Singapore","OTHER",[8,12,15,17],{"label":9,"type":10,"description":11,"interventionNames":10},"A",null,"1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography\n2. Bio-specimen collection\n3. Six-minute walk test\n4. Musculoskeletal Analysis\n5. Cardiopulmonary exercise test",{"label":13,"type":10,"description":14,"interventionNames":10},"B","1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography\n2. Bio-specimen collection\n3. Six-minute walk test\n4. Musculoskeletal Analysis",{"label":16,"type":10,"description":14,"interventionNames":10},"C",{"label":18,"type":10,"description":19,"interventionNames":10},"D","1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography\n2. Bio-specimen collection\n3. Six-minute walk test (may require separate day visit to complete)\n4. Musculoskeletal Analysis\n5. Questionnaires",[21],{"facility":5,"status":22,"city":23,"state":23,"zip":24,"country":23,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"RECRUITING","Singapore","169609",{"type":26,"coordinates":27},"Point",[28,29],103.85007,1.28967,{"lat":29,"lon":28},[32,37],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Angela Koh, M.D.","CONTACT","67042228","angela.koh.s.m@singhealth.com.sg",{"name":38,"role":39,"phone":10,"phoneExt":10,"email":10},"Angela Koh, M.D","PRINCIPAL_INVESTIGATOR",{"type":41,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100498840",false,"NCT05775484","Exercise to Slow Cardiovascular Ageing Progression","Inclusion Criteria:\n\n* Age \\>=21 years old\n* Outdoor ambulant\n\nExclusion Criteria:\n\n* Wheelchair or bed-bound\n* Dementia\n* Residing in sheltered or nursing home\n* Cancer\n* Participation in ongoing clinical trials that involve interventional drugs or devices\n* Aneurysms\n* Acute infections (in the last six months)\n* Uncontrolled thyrotoxicosis\n* Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise\n* Uncontrolled asthma or chronic lung disease\n* Restrictive lung disease",true,"ALL","21 Years","100 Years",{"count":52,"type":53},450,"ESTIMATED","OBSERVATIONAL","In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.",[57,58,59],"Cardiac Ageing","Exercise","Cardiovascular","2025-06-03",{"date":62,"type":63},"2025-06-05","ACTUAL",{"date":65,"type":63},"2023-05-01",{"date":67,"type":53},"2050-12-31",{"name":5,"class":6},1]