The EXPAND study is a prospective observational study designed to investigate the biological mechanisms underlying the heterogeneity of type 2 diabetes and related metabolic disorders.
The study will enroll adults with and without pancreatic disease, including patients undergoing pancreatic surgery, individuals with chronic pancreatitis, subjects at high risk of type 2 diabetes, and patients with newly diagnosed type 2 diabetes. Clinical, metabolic, imaging, genetic, microbiome, and molecular data will be integrated to identify distinct metabolic endotypes and to investigate the interactions between the exocrine pancreas, endocrine pancreas, and adipose tissue. The ultimate goal is to improve the understanding of diabetes pathophysiology and support the development of precision medicine approaches.
Adults aged 20 to 78 years.
Ability and willingness to provide written informed consent.
Individuals undergoing pancreatectomy for non-endocrine pancreatic disease.
Individuals with pancreatic ductal adenocarcinoma undergoing pancreatectomy.
Age <20 years or >78 years.
Inability or unwillingness to provide informed consent.
Pregnancy or breastfeeding.
Diagnosis of type 1 diabetes mellitus.
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lead sponsor