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Ematologia","Trieste",{"type":33,"coordinates":280},[281,282],13.77678,45.64953,{"lat":282,"lon":281},[285,289],{"name":286,"role":20,"phone":287,"phoneExt":10,"email":288},"Elisa Lucchini, MD","+390403992677","elisa.lucchini@asugi.sanita.fvg.it",{"name":286,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":291,"status":102,"city":292,"state":10,"zip":10,"country":31,"cosmosGeoPoint":293,"geoPoint":297,"contacts":298},"A.O.U.I. di Verona - Ematologia","Verona",{"type":33,"coordinates":294},[295,296],10.9938,45.43854,{"lat":296,"lon":295},[299,303],{"name":300,"role":20,"phone":301,"phoneExt":10,"email":302},"Francesca Maria Quaglia, MD","+390458124827","francescamaria.quaglia@aovr.veneto.it",{"name":300,"role":16,"phone":10,"phoneExt":10,"email":10},{"type":305,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100561287",false,"NCT06588205","Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma","Multicenter, Observational, Retrospective-prospective Study Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma","FIL_MIMYC","Inclusion Criteria:\n\n* Diagnosis of nodal and extranodal Diffuse Large B Cell Lymphoma, High Grade B Cell Lymphomas (including low-grade transformed lymphomas; double and triple hit; 11q aberration; not otherwise specified) after 1st January 2019\n* Presence of one MYC translocation or gain of copies (GCN: \\> 3 copies in more than 30% of the nuclei) or amplification evaluated by FISH\n* Availability of immunohistochemical analysis of CD10, Bcl6, MUM1, Bcl2, Myc, Ki67\n* Have received curative treatment (e.g. R-CHOP, R DA EPOCH, intensified \"Burkitt like\" chemotherapies) as first-line therapy\n* Histological material of adequate size and quality to perform histological review with any additional investigations (immunohistochemistry, FISH and other molecular analysis). A FFPE block must be provided for patient enrollment.\n* Age between 18 and 79 years\n\nExclusion Criteria:\n\n* Primary lymphomas of the central nervous system, plasmablastic lymphoma, Burkitt's lymphoma, primary mediastinal B lymphoma\n* Have received palliative treatment","ALL","18 Years","79 Years",{"count":317,"type":318},200,"ESTIMATED","OBSERVATIONAL","This is a observational, retrospective and prospective study designed to assess the potential correlations between MYC alterations, lymphoma mutational landscape and functional immune contextures in Diffuse Large B-cell Lymphoma or High-Grade B-cell Lymphoma",[322,323,324],"Diffuse Large B Cell Lymphoma","High-grade B-cell Lymphoma","High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements",[322,323,326,327,328,329,330,331],"MYC","BCL2","BCL6","Double Hit","Triple Hit","lymphoma micro-environment","2025-12-22",{"date":334,"type":335},"2025-12-29","ACTUAL",{"date":337,"type":335},"2025-05-05",{"date":339,"type":318},"2027-12",{"name":5,"class":6},20]