[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574235":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":45,"studyPopulation":38,"armGroups":46,"interventions":64,"overallOfficials":78,"centralContacts":83,"locations":92,"responsibleParty":111,"collaborators":38,"id":114,"slug":38,"hasResults":115,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":38,"eligibilityCriteria":119,"healthyVolunteers":115,"sex":120,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":38,"studyType":126,"phases":127,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":95,"whyStopped":38,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},{"fullName":5,"class":6},"National Cheng Kung University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":38},[9,13],{"measure":10,"description":11,"timeFrame":12},"Oxygen consumption (VO2)","Oxygen consumption examined by cardiopulmonary exercise test","Change from baseline (0 week) to follow up (20 weeks)",{"measure":14,"description":15,"timeFrame":12},"Diaphragm capacity","Diaphragm capacity examined by diaphragmatic ultrasound",[17,20,23,26,29,32,35],{"measure":18,"description":19,"timeFrame":12},"Functional capacity","Functional capacity examined by 6MWT",{"measure":21,"description":22,"timeFrame":12},"Heart Rate Variability","Heart Rate Variability examined by autonomic nervous system",{"measure":24,"description":25,"timeFrame":12},"Pulmonary function test","Pulmonary function test examined by spirometer. Spirometry is a physiological test that measures the ability to inhale and exhale air over time. The main spirometry results are forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and the FEV1\u002FFVC ratio.",{"measure":27,"description":28,"timeFrame":12},"Maximum respiratory pressure","Maximum respiratory pressure examined by pressure meter",{"measure":30,"description":31,"timeFrame":12},"Quality of life score (COPD-related questionnaire-I)","Quality of life score examined by mMRC Questionnaire.",{"measure":33,"description":34,"timeFrame":12},"Quality of life score (COPD-related questionnaire-II)","COPD Assessment Test (CAT) questionaire",{"measure":36,"description":37,"timeFrame":12},"Quality of life score (COPD-related questionnaire-III)","St George's Respiratory Questionnaire (SGRQ)",null,{"allocation":40,"interventionModel":41,"interventionModelDescription":38,"primaryPurpose":42,"observationalModel":38,"timePerspective":38,"maskingInfo":43},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":44,"maskingDescription":38,"whoMasked":38},"NONE","The systemic effects of Chronic Obstructive Pulmonary Disease (COPD) can precipitate a series of complications, including cardiovascular disorders, muscle atrophy, and osteoporosis. These comorbid conditions often result in decreased physical activity and suboptimal physical fitness, compelling patients to lead a sedentary lifestyle to mitigate exercise-induced dyspnea. Addressing the limitations in exercise tolerance remains a critical therapeutic goal in the treatment of COPD. According to research, exercise intolerance is caused by both poor pulmonary function and associated skeletal muscle dysfunction. Blood flow restriction training, a new rehabilitation technique, has shown promise in improving muscular strength at lower exercise intensities and in shorter timeframes, presenting a fresh approach to COPD rehabilitation.\n\nThe research aims to investigate the impact of incorporating blood flow restriction training into a holistic aerobic exercise program on exercise capacity and quality of life among patients with COPD. The findings are intended to clarify the potential of this innovative training technique as a supplementary therapeutic strategy in the management of COPD.",[47,53,59],{"label":48,"type":49,"description":50,"interventionNames":51},"Usual care group","ACTIVE_COMPARATOR","The Usual care group will receive COPD and exercise-related education.",[52],"Behavioral: Disease and exercise suggestion",{"label":54,"type":55,"description":56,"interventionNames":57},"Aerobic exercise group-cycling","EXPERIMENTAL","The aerobic exercise group will receive cycling training intervention 2-3 times per week for 2 months.",[58],"Behavioral: Aerobic exercise intervention",{"label":60,"type":55,"description":61,"interventionNames":62},"BFR group-cycling + BFR","The BFR group will receive cycling training combined with BFR intervention 2-3 times per week for 2 months.",[63],"Behavioral: Blood flow restriction (BFR) intervention",[65,70,74],{"type":66,"name":67,"description":68,"armGroupLabels":69,"otherNames":38},"BEHAVIORAL","Aerobic exercise intervention","The aerobic exercise intervention will utilize an ergometer. The program will be conducted 2-3 times per week over a 3-month period.",[54],{"type":66,"name":71,"description":72,"armGroupLabels":73,"otherNames":38},"Disease and exercise suggestion","The participants will be provided by educational program about COPD self-care and home-based exercise approach.",[48],{"type":66,"name":75,"description":76,"armGroupLabels":77,"otherNames":38},"Blood flow restriction (BFR) intervention","Blood flow restriction (BFR) intervention will combine aerobic exercise on the ergometer with BFR training. The program will be conducted 2-3 times per week over a 3-month period.",[60],[79],{"name":80,"affiliation":81,"role":82},"Kun-Ling Tsai, Ph.D.","Department of Physical Therapy, National Cheng Kung University","PRINCIPAL_INVESTIGATOR",[84,89],{"name":80,"role":85,"phone":86,"phoneExt":87,"email":88},"CONTACT","886-6-2353535","5078","kunlingtsai@mail.ncku.edu.tw",{"name":90,"role":85,"phone":86,"phoneExt":87,"email":91},"Yu-Ting Huang, M.S.","t66061053@pt.ncku.edu.tw",[93],{"facility":94,"status":95,"city":96,"state":97,"zip":98,"country":97,"countryCode":99,"cosmosGeoPoint":100,"geoPoint":105,"contacts":106},"National Cheng Kung University Hostipal","RECRUITING","Tainan","Taiwan","701","TW",{"type":101,"coordinates":102},"Point",[103,104],120.21333,22.99083,{"lat":104,"lon":103},[107],{"name":108,"role":85,"phone":109,"phoneExt":110,"email":88},"Kun-Ling Tsai, PhD","062353535","6219",{"type":82,"investigatorFullName":112,"investigatorTitle":113,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"Kun-Ling Tsai","Professor and Chair, Department of Physical Therapy","100574235",false,"NCT06756646","Exploring the Effects of Aerobic Exercise Combined with BFRT on Patients with COPD","Exploring the Effects of Aerobic Exercise Combined with Blood Flow Restriction Training on Exercise Capacity, Cardiopulmonary Functions, and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n1. COPD classified as levels 2-4.\n2. Stable condition without worsening in the past three months.\n3. No participation in any rehabilitation program within the past six months.\n4. Ability to understand and follow verbal commands and cooperate with an exercise training program.\n\nExclusion Criteria:\n\n1. Unconscious or unable to cooperate with the evaluator.\n2. Hospitalization due to acute illness within the past three months.\n3. Severe joint diseases or history of lower limb surgery.\n4. Severe cardiovascular disease (e.g., presence of a cardiac pacemaker or acute myocardial infarction within the past six months).\n5. Dependence on oxygen supply.","ALL","30 Years","85 Years",{"count":124,"type":125},90,"ESTIMATED","INTERVENTIONAL",[128],"NA","Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in COPD patients.",[131],"Chronic Obstructive Pulmonary Disease",[133,131],"Blood flow restriction training","2024-12-25",{"date":136,"type":137},"2025-01-03","ACTUAL",{"date":139,"type":137},"2024-11-20",{"date":141,"type":125},"2030-12-31",{"name":5,"class":6},1]