[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100494962":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":20,"studyPopulation":20,"armGroups":26,"interventions":32,"overallOfficials":20,"centralContacts":38,"locations":48,"responsibleParty":70,"collaborators":72,"id":82,"slug":20,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":83,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":20,"studyType":95,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":51,"whyStopped":20,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Associazione Italiana per lo Studio del Pancreas","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Presence - absence of predisposing mutations","Prevalence of genetic mutations over the total tested","5 years",[14,17],{"measure":15,"description":16,"timeFrame":12},"Correlation of genetic mutations with personal oncological history","Correlation between presence of predisposing mutation and prevalence of cancers",{"measure":18,"description":19,"timeFrame":12},"Correlation of genetic mutations with familial oncological history","Correlation between presence of predisposing mutation and prevalence of cancers in the family",null,{"allocation":22,"interventionModel":23,"interventionModelDescription":20,"primaryPurpose":6,"observationalModel":20,"timePerspective":20,"maskingInfo":24},"NA","SINGLE_GROUP",{"masking":25,"maskingDescription":20,"whoMasked":20},"NONE",[27],{"label":28,"type":6,"description":29,"interventionNames":30},"Saliva testing swab","Subjects with familiarity with pancreatic cancer enrolled into the IRFARPC registry (NCT04095195) will be submitted to buccal swab for saliva-based genetic testing",[31],"Genetic: Saliva swab testing",[33],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":20},"GENETIC","Saliva swab testing","41 pancreatic cancer predisposition genes will be tested through a saliva-based swab",[28],[39,44],{"name":40,"role":41,"phone":42,"phoneExt":20,"email":43},"Erica Secchettin, PharmD","CONTACT","0458126254","familiarita.aisp@gmail.com",{"name":45,"role":41,"phone":46,"phoneExt":20,"email":47},"AISP Association","340 2713112","aisp.ricerca@gmail.com",[49],{"facility":50,"status":51,"city":52,"state":20,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Chirurgia generale e del Pancreas Azienda Ospedaliera Universitaria Integrata","RECRUITING","Verona","37136","Italy","IT",{"type":57,"coordinates":58},"Point",[59,60],10.9938,45.43854,{"lat":60,"lon":59},[63,67],{"name":64,"role":41,"phone":65,"phoneExt":20,"email":66},"Salvatore Paiella, MD, PhD","+390458126009","salvatore.paiella@univr.it",{"name":40,"role":41,"phone":68,"phoneExt":20,"email":69},"+390458126254","erica.secchettin@univr.it",{"type":71,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[73,76,78,80],{"name":74,"class":75},"General and Pancreatic Surgery Unit, University of Verona","UNKNOWN",{"name":77,"class":75},"Fondazione Valsecchi",{"name":79,"class":75},"Associazione Oltre La Ricerca",{"name":81,"class":75},"Genomica srl","100494962",false,"NCT05724992","Familial Pancreatic Cancer PROPHilation Program in Italy","Standardised Genetic Profiling of Subjects Belonging to the Italian Multicenter Registry of Prospective Surveillance of Subjects at Genetic Risk of Pancreatic Cancer","PROPH-ITA","Inclusion Criteria:\n\n* Being enrolled on the IRFARPC registry\n* Having familiarity for pancreatic cancer (according to the IRFARPC criteria, Capurso et al. Dig Liv Dis, 2020)\n* Willingness to participate in saliva-swab-based genetic testing\n\nExclusion Criteria:\n\n\\- Already known genetic mutation","ALL","18 Years","80 Years",{"count":93,"type":94},3000,"ESTIMATED","INTERVENTIONAL",[22],"The goal of the PROPH-ITA Study is to perform genetic testing in family members of pancreatic cancer patients who may have a genetic predisposition. The subjects belong to the Italian Registry of Families At Risk of Pancreatic Cancer (IRFARPC, #NCT04095195). This investigational study will assess the genetic background of subjects with familiarity with pancreatic cancer only.\n\nParticipants may accept to undergo genetic testing as part of the IRFARPC registry, through a saliva-swab-based 41-gene panel test.\n\nUp to 3,000 participants will be enrolled in this study.",[99],"Candidates for Hereditary Pancreatic Cancer Testing",[101,102,103,104,105],"Pancreatic Cancer","Pancreatic Cancer familiarity","Genetic profiling","Genetic predisposition","Pancreatic Cancer surveillance","2023-02-13",{"date":108,"type":109},"2023-02-15","ACTUAL",{"date":111,"type":109},"2022-12-20",{"date":113,"type":94},"2028-12-20",{"name":5,"class":6},1]