[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633992":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":37,"responsibleParty":52,"collaborators":54,"id":60,"slug":24,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":40,"whyStopped":24,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Probiotic","EXPERIMENTAL","8 week probiotic supplementation, followed by 6 weeks wash-out and 8 weeks oberservation",[13],"Other: Probiotic Formula",{"label":15,"type":6,"description":16,"interventionNames":17},"Observation","8 week observation, followed by 6 weeks washout and 8 week probiotic supplementation",[18],"Other: Observation",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Probiotic Formula","multi-strain probiotics",[9],null,{"type":6,"name":15,"description":15,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"affiliation":30,"role":31},"Christiane Sokollik, Prof","Division of Paediatric Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland","PRINCIPAL_INVESTIGATOR",[33],{"name":29,"role":34,"phone":35,"phoneExt":24,"email":36},"CONTACT","+41 31 632 21 11","christiane.sokollik@insel.ch",[38],{"facility":39,"status":40,"city":41,"state":24,"zip":24,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Inselspital, Universitätsspital Bern Kinderklinik","RECRUITING","Bern","Switzerland",{"type":44,"coordinates":45},"Point",[46,47],7.44744,46.94809,{"lat":47,"lon":46},[50],{"name":51,"role":34,"phone":35,"phoneExt":24,"email":36},"Christiane Sokollik, PD Dr. med.",{"type":53,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[55,58],{"name":56,"class":57},"Clinical Trials Unit University of Bern","UNKNOWN",{"name":59,"class":6},"University of Bern","100633992",false,"NCT07533890","Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Children and Adolescents With Inflammatory Bowel Disease","Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Children and Adolescents With Inflammatory Bowel Disease - an Explanatory 1:1 Randomized Controlled Cross-Over Proof-of-Concept Trial With Blinded Outcome Assessment","MicroSig","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosis of inflammatory bowel disease according to actual guidelines (Porto Criteria)\n* General good health\n* Ability to understand and follow study procedures and understand informed consent\n* Age 5 -18 years\n* No probiotic therapy 4 weeks before entering into the study.\n\nExclusion Criteria:\n\n* Participation in other clinical studies interfering with study procedures.\n* Inability or contraindications to undergo the investigated intervention\n* Severe or acute flare of disease (for UC PUCAI score ≥35, for CD wPCDAI \\>40)\n* Treatment escalation within last 4 weeks for uncontrolled disease.\n* Antibiotic or probiotic therapy within the last 4 weeks.","ALL","5 Years","18 Years",{"count":71,"type":72},40,"ESTIMATED","INTERVENTIONAL",[75],"NA","In this study the intestinal microbiome and metabolic profiles of patients with inflammatory bowel disease will be determined upon probiotic intervention.",[78],"Inflamatory Bowel Disease",[80,81,82],"microbiome","inflammatory bowel disease","probiotics","2026-06-29",{"date":85,"type":86},"2026-06-30","ACTUAL",{"date":88,"type":86},"2026-05-01",{"date":90,"type":72},"2028-12",{"name":5,"class":6},1]