[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594867":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":26,"studyPopulation":27,"armGroups":28,"interventions":22,"overallOfficials":22,"centralContacts":32,"locations":39,"responsibleParty":64,"collaborators":22,"id":66,"slug":22,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":22,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":22,"enrollmentInfo":75,"targetDuration":22,"studyType":78,"phases":22,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":56,"whyStopped":22,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"National University of Malaysia","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":22},[9,13],{"measure":10,"description":11,"timeFrame":12},"Maternal serum level of progesterone","Maternal blood will be withdrawn and serum isolated. Measurement of progesterone level will be performed from the serum sample using ELISA.","At the point of recruitment from 24 until 32 weeks gestation.",{"measure":14,"description":15,"timeFrame":16},"Placental immunoexpression of Heme Oxygenase 1","Immunoexpression of Heme Oxygenase 1 in syncytiotrophoblasts, cytotrophoblasts, fetal endothelial cells, maternal vessels and decidual cells.","At delivery within 24 until 38 weeks gestation.",[18],{"measure":19,"description":20,"timeFrame":21},"Placenta histopathology examination","Placenta will be examined histopathologically","At delivery within 24 until 38 weeks gestation",null,{"allocation":22,"interventionModel":22,"interventionModelDescription":22,"primaryPurpose":22,"observationalModel":24,"timePerspective":25,"maskingInfo":22},"CASE_CONTROL","PROSPECTIVE","The study aims to investigate the relationship between maternal serum level of progesterone, immune-expression of HMOX-1 a placental angiogenesis marker with idiopathic fetal growth restriction.","Women diagnosed to have fetal growth restriction within 24 until 32 weeks gestation the absence of hypertension, diabetes or autoimmune disease.",[29],{"label":30,"type":22,"description":31,"interventionNames":22},"Women with pregnancies affected by idiopathic fetal growth restriction","Women with normal pregnancies and normally growing foetus",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Rahana Abd Rahman, MOG (UKM)","CONTACT","+60122719985","5964","drrahana@hctm.ukm.edu.my",[40,55],{"facility":41,"status":42,"city":43,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hospital Canselor Tuanku Muhriz","NOT_YET_RECRUITING","Kuala Lumpur","56000","Malaysia","MY",{"type":48,"coordinates":49},"Point",[50,51],101.68653,3.1412,{"lat":51,"lon":50},[54],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},{"facility":41,"status":56,"city":43,"state":22,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"RECRUITING",{"type":48,"coordinates":58},[50,51],{"lat":51,"lon":50},[61],{"name":62,"role":35,"phone":22,"phoneExt":22,"email":63},"Rahana Rahman","drrahana@ukm.edu.my",{"type":65,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100594867",false,"NCT07025031","Fetal Growth Restriction a Case Control Study","Maternal Serum Progesterone And Placental Heme Oxgenase-1 Expression In Early Onset Idiopathic Fetal Growth Restriction: A Case Control Study","Inclusion Criteria:\n\n* singleton\n* dated pregnancy\n\nExclusion Criteria:\n\n* fetus with structural or chromosomal anomaly\n* receive treatments such as aspirin, progestogen, low molecular weight heparin\n* has pre-existing medical disorders such as autoimmune disease, hypertension, diabetes\n* smoking\n* suspected intrauterine infection",true,"FEMALE","19 Years",{"count":76,"type":77},58,"ESTIMATED","OBSERVATIONAL","The study aims to investigate the responsible factors that leads to idiopathic fetal growth restriction.",[81],"Idiopathic Fetal Growth Restriction",[83,84,85],"progesterone","Heme Oxygenase-1","Idiopathic fetal growth restriction","2026-06-15",{"date":88,"type":89},"2026-06-16","ACTUAL",{"date":91,"type":89},"2025-07-01",{"date":93,"type":77},"2027-04-01",{"name":5,"class":6},2]