[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100396242":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":43,"collaborators":10,"id":46,"slug":10,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":70,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Boston Children's Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"CXL group",null,"Patients who are about to undergo a corneal cross-linking (CXL) surgery to treat keratoconus.",{"label":13,"type":10,"description":14,"interventionNames":10},"Control group","Healthy volunteers age and sex matched to the CXL group.",[16],{"name":17,"affiliation":5,"role":18},"Eric A Moulton, OD PhD","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","617-919-6827","eric.moulton@childrens.harvard.edu",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Nicholas J Pondelis, BA","617-919-1895","nicholas.pondelis@childrens.harvard.edu",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Boston","Massachusetts","02115","United States",{"type":36,"coordinates":37},"Point",[38,39],-71.05977,42.35843,{"lat":39,"lon":38},[42],{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},{"type":18,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Eric Moulton","Assistant Professor of Anesthesia","100396242",false,"NCT04439552","fMRI and IVCM Cornea Microscopy of CXL in Keratoconus","Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus","Inclusion Criteria:\n\nCXL Group\n\n* Age 8-35 years\n* Clinical diagnosis of keratoconus and seeking CXL treatment\n* English speaking ability sufficient to comprehend consent with parental assistance\n* MRI compatible\n* Ability to lie still for an MRI session (60 minutes)\n\nControl Group\n\n* Age 8-35 years\n* No diagnosis of keratoconus\n* English speaking ability sufficient to comprehend consent with parental assistance\n* MRI compatible\n* Ability to lie still for an MRI session (60 minutes)\n\nExclusion Criteria (Both Groups):\n\n* Claustrophobic\n* Weight \\> 285 lbs (weight limit of the MRI table)\n* Significant medical history, including:\n\nCurrent DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes\n\n* Magnetic implants or metal-containing tattoos on their chest or above\n* Pregnancy\n* History of contact lens wear\n* Any allergic response to a numbing eyedrop in the past",true,"ALL","8 Years","35 Years",{"count":57,"type":58},60,"ESTIMATED","OBSERVATIONAL","Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).",[62,63,64,65,66,67,68,69],"Pain, Postoperative","Pain, Chronic","Pain, Acute","Surgical Injury","Surgical Wound","Cornea Injury","Cornea","Keratoconus",[71,72,73,74],"fMRI","Corneal Microscopy","IVCM","Neuroimaging","2025-12-15",{"date":77,"type":78},"2025-12-19","ACTUAL",{"date":80,"type":78},"2021-10-04",{"date":82,"type":58},"2027-12",{"name":5,"class":6},1]