[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566142":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":48,"collaborators":50,"id":54,"slug":10,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":74,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Methadone",null,"Participants initiated into methadone within the past 6 months will receive fMRI and cognitive assessment battery.",[13],"Diagnostic Test: fMRI",{"label":15,"type":10,"description":16,"interventionNames":17},"Buprenorphrine","Participants initiated into buprenorphine within the past 6 months will receive fMRI and cognitive assessment battery.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","fMRI","Participants will be performing tasks while undergoing fMRI. Tasks include Stroop task, Emotion-regulation task and an Ambiguity reward task, Drug cue task, and Cognitive behavioral therapy task. Participants are not presented with any specific stimulus.",[15,9],[25],{"name":26,"affiliation":5,"role":27},"Sarah Yip, PhD, MSc","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Monica Holler, BS","CONTACT","203 737 3531","monica.holler@yale.edu",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":10},"The APT Foundation","RECRUITING","New Haven","Connecticut","06520","United States",{"type":43,"coordinates":44},"Point",[45,46],-72.92816,41.30815,{"lat":46,"lon":45},{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[51],{"name":52,"class":53},"National Institute on Drug Abuse (NIDA)","NIH","100566142",false,"NCT06651333","fMRI and Opioid Abstinence","Functional Connectivity Mechanisms of Opioid Abstinence","Inclusion Criteria:\n\n* recent initiation of methadone or buprenorphine at a clinic or program within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest);\n* eligibility for MRI scanning;\n* ability to commit to study visits.\n\nExclusion Criteria:\n\n* current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;\n* current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;\n* severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore \\\u003C30 (i.e., severe impairment)\n* past or present history of intellectual disability, developmental disorder, or neurological disease;\n* head trauma with loss of consciousness \\>30 min;\n* organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.","ALL","18 Years","50 Years",{"count":64,"type":65},240,"ESTIMATED","OBSERVATIONAL","This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.",[69,70,71,72,73],"Drug Use Disorder","Opioid Dependence","Opioid-Related Disorders","Opioid Use","Opioid Abuse",[75],"Relapse","2025-10-16",{"date":78,"type":79},"2025-10-20","ACTUAL",{"date":81,"type":79},"2024-12-12",{"date":83,"type":65},"2029-11",{"name":5,"class":6},1]