[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100488436":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":65,"collaborators":18,"id":67,"slug":18,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":18,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":18,"enrollmentInfo":75,"targetDuration":18,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Emotion network up-regulation + standard care","EXPERIMENTAL","NF protocol targeting emotion networks (NFE) (plus standard care)",[13],"Other: fMRI-based neurofeedback",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard care","NO_INTERVENTION","Continuation of treatment as usual.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"fMRI-based neurofeedback","Participants use fMRI-based neurofeedback to train the upregulation of brain areas that respond to positive affective pictures (as identified during a functional localiser scan).",[9],[25],{"name":26,"affiliation":27,"role":28},"David E Linden, Prof.","Professor of Translational Neuroscience","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":18,"email":33},"CONTACT","+31 43 3881021","david.linden@maastrichtuniversity.nl",[35,50,56],{"facility":36,"status":37,"city":38,"state":18,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Mondriaan Zorggroep","RECRUITING","Maastricht","6226NB","Netherlands",{"type":42,"coordinates":43},"Point",[44,45],5.68889,50.84833,{"lat":45,"lon":44},[48],{"name":49,"role":31,"phone":18,"phoneExt":18,"email":18},"Rob Havermans, Dr.",{"facility":51,"status":37,"city":38,"state":18,"zip":52,"country":40,"cosmosGeoPoint":53,"geoPoint":55,"contacts":18},"Maastricht University","6229ER",{"type":42,"coordinates":54},[44,45],{"lat":45,"lon":44},{"facility":57,"status":37,"city":38,"state":18,"zip":58,"country":40,"cosmosGeoPoint":59,"geoPoint":61,"contacts":62},"Maastricht UMC+","6229HX",{"type":42,"coordinates":60},[44,45],{"lat":45,"lon":44},[63],{"name":64,"role":31,"phone":18,"phoneExt":18,"email":18},"Bart Rutten, Professor",{"type":66,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100488436",false,"NCT05640089","FMRI-neurofeedback in Depression","A Randomised Controlled Trial of FMRI-neurofeedback in Depression","Inclusion Criteria:\n\n* Diagnosis of a depressive disorder (ICD-10: F32 or F33)\n* Has been on stable antidepressant medication (single or combination treatment) for at least 4 weeks\n* Current depression (QIDS \\>= 17)\n* If required to meet recruitment targets the minimum entry score will be reduced QIDS \\>= 13 (i.e. still corresponding to a moderate level of depression)\n\nExclusion Criteria:\n\n* Exclusion criteria for MRI (e.g. cardiac pacemaker, certain metallic implants)\n* History of psychotic disorder bipolar disorder, or psychotic depression\n* Current use of illegal drugs (any in the last four weeks)\n* Current excessive alcohol consumption that interferes with daily functioning\n* History of neurological disease that could influence the fMRI signal and\u002For the anatomical alignment (e.g. territorial stroke, multiple sclerosis, brain tumour)","ALL","18 Years",{"count":76,"type":77},120,"ESTIMATED","INTERVENTIONAL",[80],"NA","Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction. The goal of this clinical trial is to compare fMRI-neurofeedback plus standard care with standard care in patients with depression.\n\nParticipants will either receive standard care, or standard care plus a fMRI neurofeedback training, consisting of 5 neurofeedback training sessions. Symptom severity will be assessed before, immediately after and 6 months after the intervention.",[83],"Depression, Unipolar",[85,86,87,88,89,90],"Depression","Depressive Disorder","Behavioral Symptoms","Mood Disorders","Mental Disorders","fMRI Neurofeedback","2025-03-20",{"date":93,"type":94},"2025-03-24","ACTUAL",{"date":96,"type":94},"2023-01-25",{"date":98,"type":77},"2027-04-30",{"name":5,"class":6},3]