This clinical trial tests the effect of focal radiation therapy, high dose rate-brachytherapy (HDR-BT), in treating patients with prostate cancer. Prostate cancer is the most diagnosed cancer in men and there are many treatments available, including surgery and radiation therapy. Although surgery and radiation therapy improve survival urinary and sexual function can be significantly affected and can be long lasting. HDR-BT, a type of focal radiation therapy also known as internal radiation therapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Giving HDR-BT may be effective in providing local control while reducing side effects in patients with prostate cancer.
Histologically confirmed diagnosis of prostate adenocarcinoma within 90 days prior to registration via systematic biopsy
Multiparametric MRI (mp-MRI) confirmed lesion(s)
No distant or locally advanced disease on standard staging exams as indicated
Bone scan and abdominopelvic computed tomography (CT)/MRI OR
Radiographic nodal or distant metastatic disease
Lesion(s) comprising > 40% of total prostate volume
Prior radiotherapy to the pelvis
Gleason score > 6 disease outside intended gross target volume (GTV)/target region(s)
Jonsson Comprehensive Cancer Center
Lead sponsor