[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450604":3},{"organization":4,"outcomesModule":7,"designInfo":13,"detailedDescription":11,"studyPopulation":11,"armGroups":18,"interventions":30,"overallOfficials":11,"centralContacts":35,"locations":42,"responsibleParty":62,"collaborators":11,"id":64,"slug":11,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":11,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":11,"overallStatus":45,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"CHU de Reims","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Premotor cortex activation in OSAS patients without CPAP",null,"Day 0",{"allocation":14,"interventionModel":15,"interventionModelDescription":11,"primaryPurpose":6,"observationalModel":11,"timePerspective":11,"maskingInfo":16},"NON_RANDOMIZED","SINGLE_GROUP",{"masking":17,"maskingDescription":11,"whoMasked":11},"NONE",[19,25],{"label":20,"type":21,"description":22,"interventionNames":23},"non-OSAS patients","ACTIVE_COMPARATOR","Patients without OSAS (Apnea-Hypopnea Index (AHI) \\\u003C 15\u002Fh and absence of excessive daytime sleepiness with Epworth score \\\u003C11)",[24],"Diagnostic Test: functional magnetic resonance imaging",{"label":26,"type":27,"description":28,"interventionNames":29},"OSAS patients","EXPERIMENTAL","Patients with severe OSAS with an Apnea-Hypopnea Index (AHI) \\> 30\u002Fh",[24],[31],{"type":32,"name":33,"description":33,"armGroupLabels":34,"otherNames":11},"DIAGNOSTIC_TEST","functional magnetic resonance imaging",[26,20],[36],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Claire Launois","CONTACT","3 26 78 83 70","0033","claunois@chu-reims.fr",[43],{"facility":44,"status":45,"city":46,"state":11,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Chu Reims","RECRUITING","Reims","51092","France","FR",{"type":51,"coordinates":52},"Point",[53,54],4.02853,49.26526,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":59,"phoneExt":60,"email":61},"Damien JOLLY","326788472","33","djolly@chu-reims.fr",{"type":63,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100450604",false,"NCT05147649","Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome","Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions","IRM SAOS","Inclusion criteria :\n\n1. OSAS patients\n\n   * severe OSAS with an Apnea-Hypopnea Index (AHI) \\> 30\u002Fh\n   * without CPAP treatment\n2. Non-OSAS patients\n\n   * absence of OSAS (AHI \\\u003C 15\u002Fh and absence of excessive daytime sleepiness with Epworth score \\\u003C11)\n\nNon-inclusion criteria :\n\n* \\\u003C 18 years old\n* \\>75 years old\n* left-handed\n* BMI\\> 40 kg\u002Fm²\n* another sleep disorder\n* central component of sleep apnea syndrome (central apnea index\\> 5 \u002F h)\n* current or past neurological pathology\n* respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)\n* MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)\n* taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.),\n* uncorrected sensory impairment (vision or hearing)\n* protected by law.\n\nExclusion criteria :\n\n* pregnant woman according to the positive beta-hCG test result\n* left-handed following the laterality questionnaire\n* MINI results showing:\n\n  * a current mood episode\n  * a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)\n  * an eating disorder\n  * a diagnosis of bipolar disorder, current or past schizophrenia",true,"ALL","18 Years","75 Years",{"count":76,"type":77},70,"ESTIMATED","INTERVENTIONAL",[80],"NA","The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.",[83],"Obstructive Sleep Apnea Syndrome","2025-11-28",{"date":86,"type":87},"2025-12-02","ACTUAL",{"date":89,"type":87},"2023-03-02",{"date":91,"type":77},"2027-07-02",{"name":5,"class":6},1]