[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577038":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":35,"centralContacts":39,"locations":48,"responsibleParty":59,"collaborators":10,"id":63,"slug":10,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Jagiellonian University","OTHER",[8,15,18],{"label":9,"type":10,"description":10,"interventionNames":11},"Women with polycystic ovary syndrome (PCOS) and insulin resistance (IR)",null,[12,13,14],"Diagnostic Test: Measurement of kisspeptin concentration","Diagnostic Test: Measurement of ghrelin concentration","Diagnostic Test: Measurement of zonulin concentration",{"label":16,"type":10,"description":10,"interventionNames":17},"Women with polycystic ovary syndrome (PCOS) without insulin resistance (IR)",[12,13,14],{"label":19,"type":10,"description":10,"interventionNames":20},"Women without PCOS",[12,13,14],[22,27,31],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Measurement of kisspeptin concentration","Measurement of kisspeptin concentration in fasting venous blood serum",[9,16,19],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Measurement of ghrelin concentration","Measurement of ghrelin concentration in fasting venous blood serum",[9,16,19],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Measurement of zonulin concentration","Measurement of zonulin concentration in fasting venous blood serum",[9,16,19],[36],{"name":37,"affiliation":5,"role":38},"Kazimierz Pityński, Prof., Ph.D., M.D.","STUDY_CHAIR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":10,"email":44},"Iwona Gawron, Ph.D., M.D.","CONTACT","+48 124248570","iwona.gawron@uj.edu.pl",{"name":46,"role":42,"phone":43,"phoneExt":10,"email":47},"Robert Jach, Prof., Ph.D., M.D.","jach@cm-uj.krakow.pl",[49],{"facility":5,"status":50,"city":51,"state":10,"zip":10,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":10},"RECRUITING","Krakow","Poland",{"type":54,"coordinates":55},"Point",[56,57],19.93658,50.06143,{"lat":57,"lon":56},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Iwona Magdalena Gawron","PhD, MD, Principal Investigator","100577038",false,"NCT06793098","Functional Proteins in Polycystic Ovary Syndrome","Assessment of the Concentrations of Functional Proteins as Potential Early Markers of Insulin Resistance in Women With Polycystic Ovary Syndrome","Inclusion Criteria:\n\n* women aged 18-45 years\n\nExclusion Criteria:\n\n* removal of at least one ovary\n* treated diabetes of any type\n* diagnosed and treated metabolic diseases\n* diagnosed and treated autoimmune diseases\n* diagnosed and treated autoinflammatory diseases",true,"FEMALE","18 Years","45 Years",{"count":74,"type":75},100,"ESTIMATED","OBSERVATIONAL","The concentration of functional proteins: kisspeptin, ghrelin, zonulin will be measured and compared in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR), in women with PCOS without IR, and in women without PCOS.",[79,80],"Reproductive Age","PCOS (Polycystic Ovary Syndrome)",[82,83,84,85,86,87],"insulin resistance","kisspeptin","ghrelin","zonulin","metabolic syndrome","Polycystic Ovary Syndrome","2026-03-17",{"date":90,"type":91},"2026-03-18","ACTUAL",{"date":93,"type":91},"2025-01-20",{"date":95,"type":75},"2027-12-31",{"name":5,"class":6},1]