[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558049":3},{"organization":4,"outcomesModule":7,"designInfo":20,"detailedDescription":26,"studyPopulation":19,"armGroups":27,"interventions":32,"overallOfficials":19,"centralContacts":38,"locations":19,"responsibleParty":48,"collaborators":19,"id":52,"slug":19,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":19,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":19,"studyType":64,"phases":65,"briefSummary":26,"conditions":66,"keywords":19,"overallStatus":68,"whyStopped":19,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":19},{"fullName":5,"class":6},"South Valley University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":19},[9],{"measure":10,"description":11,"timeFrame":12},"Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls.","1- Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls.techniques in patients with generalized vitiligo and compare it with healthy controls.","three months",[14,16],{"measure":15,"description":15,"timeFrame":12},"2- Evaluation expression of tissue Gasdermin D using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet B therapy.",{"measure":17,"description":18,"timeFrame":12},"3- Determine whether there is a correlation between tissue immunehistochemstry Gasdermin D levels and disease duration and involved body surface area (VISA) in vitiligo patients.","3- Determine whether there is a correlation between tissue immunehistochemstry D levels and disease duration and involved body surface area (VISA) in vitiligo patients.",null,{"allocation":21,"interventionModel":22,"interventionModelDescription":19,"primaryPurpose":23,"observationalModel":19,"timePerspective":19,"maskingInfo":24},"NA","SINGLE_GROUP","TREATMENT",{"masking":25,"maskingDescription":19,"whoMasked":19},"NONE","The aim of this study is to:\n\n1. Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls.\n2. Evaluation expression of tissue Gasdermin D using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet B therapy.\n3. Determine whether there is a relationship between Gasdermin D levels and disease duration and involved body surface area (VISA) in vitiligo patients.",[28],{"label":29,"type":6,"description":19,"interventionNames":30},"one group",[31],"Device: narrow band ultraviolet-B",[33],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":19},"DEVICE","narrow band ultraviolet-B","vitiligo patients will recevie twice sessions per week",[29],[39,44],{"name":40,"role":41,"phone":42,"phoneExt":19,"email":43},"Soheir Abdel-Hamid, MD","CONTACT","01066877343","soher.abdel-hamid@med.svu.edu.eg",{"name":45,"role":41,"phone":46,"phoneExt":19,"email":47},"Basma Tito Abd Elhameed, MD","01020304210","Basma.tito@med.svu.edu.eg",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Soheir Abdelhamid","Soheir Abdel-Hamid, principle investigator","100558049",false,"NCT06546059","Gasdermin D Expression in Generalized Vitiligo Patients After Narrow-band Ultraviolet B Therapy","Inclusion Criteria:\n\n* Patients with stable vitiligo of 6 months duration,\n* Both sex and ages(10-75)\n\nExclusion Criteria:\n\n* pregnancy,\n* lactation,\n* patients under or previous phototherapy,\n* patients on other immunosuppressives,\n* patients receiving topical or systemic therapy like antioxidants and vitamins were kept off treatment for 2 weeks prior to recruitment into the study.",true,"ALL","10 Years","75 Years",{"count":62,"type":63},40,"ESTIMATED","INTERVENTIONAL",[21],[67],"Vitiligo, Generalized","NOT_YET_RECRUITING","2024-08-08",{"date":71,"type":72},"2024-08-09","ACTUAL",{"date":74,"type":63},"2024-08",{"date":76,"type":63},"2024-11",{"name":5,"class":6}]