[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100062089":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":28,"responsibleParty":48,"collaborators":10,"id":50,"slug":10,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":10,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Non-sibling relative",null,"18 years of age or older",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients (index cases)","Patients (index cases), 6 months of age or older",{"label":16,"type":10,"description":17,"interventionNames":10},"Siblings","Siblings, 6 months of age or older",[19],{"name":20,"affiliation":21,"role":22},"Warren J Leonard, M.D.","National Heart, Lung, and Blood Institute (NHLBI)","PRINCIPAL_INVESTIGATOR",[24],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","(301) 496-0098","wl2w@nih.gov",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States",{"type":37,"coordinates":38},"Point",[39,40],-77.10026,38.98067,{"lat":40,"lon":39},[43],{"name":44,"role":25,"phone":45,"phoneExt":46,"email":47},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100062089",false,"NCT00055172","Genetic Basis of Immunodeficiency","The Determination of Genetic Basis Of Immunodeficiency","* INCLUSION CRITERIA:\n\nIndex cases to be included are those with diminished numbers of T cells and\u002For NK cells and\u002For B cells or other immune cells or those who have normal numbers of T cell, B cells, NK cells and other immune cells but diminished function of one or more immune cells. Relatives of affected individuals may also be studied\n\n* Patients (index cases): 6 months of age and older\n* Siblings: 6 months of age and older\n* Non-sibling relatives (biological parent, aunt, uncle or grandparent): 18 years or older\n\nEXCLUSION CRITERIA:\n\n* Patients with a known diagnosis\n* Patients with a particular immunological phenotype that is not of interest to the research conducted under this study.\n* Pregnancy or lactation\n* Adults with current decisional impairment","ALL","6 Months","99 Years",{"count":60,"type":61},100,"ESTIMATED","OBSERVATIONAL","This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID).\n\nPatients with immunodeficiencies may be eligible for this study. Candidates include:\n\n* Patients with diminished numbers of T cells or NK cells or both, or\n* Patients with normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function.\n\nRelatives of patients will also be studied.\n\nParticipants will have blood samples collected for genetic analysis in studies related to SCID at the National Institutes of Health and other institutions.",[65],"Severe Combined Immunodeficiency",[67,68,69],"Cytokines","Inherited Immunodeficiency","Natural History","2026-06-17",{"date":72,"type":73},"2026-06-18","ACTUAL",{"date":75,"type":73},"2004-04-05",{"name":21,"class":6},1]