[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641833":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":25,"locations":31,"responsibleParty":61,"collaborators":65,"id":68,"slug":10,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Jan Kochanowski University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"patients with BMI>27",null,"tirzepatide treatment",[13,14],"Diagnostic Test: genetic polymorphism","Diagnostic Test: gut microbiome",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","genetic polymorphism","GLP1 RA and GIP R polymorphisms will be assesed from venous blood samples",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"gut microbiome","stool samples and oral cavity swabs for gut microbiome will be collected to assess V3 and V4 of gene 16s rRNA",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Zbigniew Siudak PI, MD, PhD","CONTACT","+48 41 349 6972","zbigniew.siudak@ujk.edu.pl",[32,48],{"facility":33,"status":34,"city":35,"state":10,"zip":10,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Waga Zmiany","RECRUITING","Krakow","Poland",{"type":38,"coordinates":39},"Point",[40,41],19.93658,50.06143,{"lat":41,"lon":40},[44],{"name":45,"role":28,"phone":46,"phoneExt":10,"email":47},"Tomasz Witaszek PI, MD","+48883992287","kontakt@wagazmiany.pl",{"facility":49,"status":34,"city":50,"state":10,"zip":10,"country":36,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Luxmed sp zoo","Warsaw",{"type":38,"coordinates":52},[53,54],21.01178,52.22977,{"lat":54,"lon":53},[57],{"name":58,"role":28,"phone":59,"phoneExt":10,"email":60},"Justyna Domienik-Karlowicz PI, MD, PhD","+48 22 450 45 00","Justyna.Domienik-Karlowicz@luxmed.pl",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zbigniew Siudak","Principal Investigator",[66],{"name":67,"class":6},"LUX MED Group","100641833",false,"NCT07650149","Genetic, Microbiological and Behavioral Factors in Obesity","OPTIMIZE GEN - Outcomes of Persistence and Treatment With tIrzepatide deterMined by Genetic, mIcrobiological & bEhavioral Factors in obEsity","OPTIMIZE-GEN","Inclusion criteria\n\n* Age 18-60 years\n* Consent to participate in the study and providing informed written consent\n* Overweight or obese with a BMI \\>27\n\nExclusion criteria\n\n* Contraindications to tirzepatide use:\n* Type 1 or type 2 diabetes\n* Pregnancy or breastfeeding\n* Cancer\n* Heart failure\n* Expected lack of patient compliance\n* Taking immunosuppressive medications, steroids, NSAIDs, antibiotics (within 2 weeks prior to sample collection),\n* Autoimmune and inflammatory diseases, acute infectious diseases, AIDS, tuberculosis\n* Mental illness\n* Alcohol dependence syndrome\n* Liver cirrhosis\n* Post-myocardial infarction or stroke","ALL","18 Years","60 Years",{"count":79,"type":80},200,"ESTIMATED","OBSERVATIONAL","This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1\u002FGIP RA in the treatment of obesity.\n\n200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.",[84,85,86],"Obesity & Overweight","Obesity","Genetics",[88,89,90,91,92,93,94],"tirzepatide","obesity","genetics","microbiom","adherence","compliance","gene","2026-06-15",{"date":97,"type":98},"2026-06-16","ACTUAL",{"date":100,"type":98},"2026-05-23",{"date":102,"type":80},"2028-05",{"name":5,"class":6},2]