[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100313213":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":24,"studyPopulation":17,"armGroups":25,"interventions":36,"overallOfficials":42,"centralContacts":46,"locations":55,"responsibleParty":73,"collaborators":75,"id":79,"slug":17,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":17,"maxAge":17,"enrollmentInfo":88,"targetDuration":17,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":17,"overallStatus":58,"whyStopped":17,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Institut Pasteur","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Identification of a susceptibility factor associated with Listeriosis infection","In patients with Listeriosis, the hypothesis that the identified genetic variation is the mutation responsible for the infection will be verified :\n\n* by verifying that it is not a listed polymorphism by sequencing genomic DNA controls\n* by verifiyng that family genetic segregation is compatible with clinical segregation\n* by verifying the function of the mutated protein in the patient's cell lines and \u002F or fresh cells\n* by performing complementation experiments by transfecting the wild-type allele into the patient's cells","10 years",[14],{"measure":15,"description":16,"timeFrame":12},"Identification of a susceptibility factor associated with the most severe or atypical forms","In patients with Listeriosis, the susceptibility factor associated with the most severe or atypical forms will be characterized :\n\n* By testing the response and production of cytokines involved in infection control.\n* By identifying chromosomal regions associated with the disease by a homozygosity mapping genetic study on multiplex and \u002F or inbred families.\n* By sequencing the identified candidate genes.",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"NON_RANDOMIZED","SINGLE_GROUP","BASIC_SCIENCE",{"masking":23,"maskingDescription":17,"whoMasked":17},"NONE","Listeriosis is a rare, severe foodborne infection caused by the bacterium Listeria monocytogenes (Lm), responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and \u002F or patients with comorbidities, with a deficit of innate or cellular immunity. Pregnancy is also a risk factor.\n\nThe Multicentric Observational NAtional Analysis of Listeriosis and Listeria (MONALISA) is an ongoing national case-control prospective study on listeriosis implemented since 2009 to study risk and prognosis factors for listeriosis. In this cohort, which enrolled 902 patients on 1 August 2014, 7% of patients with neurolisteriosis are under 40 years of age and have no identified risk factor. Genetic susceptibility is suspected in these patients. Genetic susceptibility could also explain the inconstant development of a neurolisteriosis or fetal infection, as well as the particular severity of some infections (death, foetal loss, neurological sequelae).\n\nThe analysis of the genetically transmitted vulnerability of Lm has not yet been studied, because of the lack of accessibility to prospective cohorts (and their DNA) for this rare and severe infection.\n\nThe aim of the study is to identify genetic susceptibility to Listeriosis that will optimize the patient care in terms of treatment and prevention.",[26,32],{"label":27,"type":28,"description":29,"interventionNames":30},"Patients with Listeriosis","EXPERIMENTAL","Patients with Listeriosis.\n\nHuman biological samples :\n\n* Blood sample\n* Skin biopsy\n* Saliva",[31],"Procedure: Human biological samples",{"label":33,"type":28,"description":34,"interventionNames":35},"Volunteers related with patients with Listeriosis","Volunteers related with patients with Listeriosis.\n\nHuman biological samples :\n\n* Blood sample\n* Skin biopsy\n* Saliva",[31],[37],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":17},"PROCEDURE","Human biological samples","* Blood sample\n* Skin biopsy\n* Saliva",[27,33],[43],{"name":44,"affiliation":5,"role":45},"Marc Lecuit","STUDY_DIRECTOR",[47,51],{"name":44,"role":48,"phone":49,"phoneExt":17,"email":50},"CONTACT","+33 1 40 61 34 20","marc.lecuit@pasteur.fr",{"name":52,"role":48,"phone":53,"phoneExt":17,"email":54},"Caroline Charlier-Woerther","+33 1 40 31 30 10","caroline.charlier@pasteur.fr",[56],{"facility":57,"status":58,"city":59,"state":17,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Centre Médical de l'Institut Pasteur","RECRUITING","Paris","75015","France","FR",{"type":64,"coordinates":65},"Point",[66,67],2.3488,48.85341,{"lat":67,"lon":66},[70],{"name":71,"role":48,"phone":72,"phoneExt":17,"email":54},"Caroline Charlier-Woerther, MD","+33 1 40 61 30 10",{"type":74,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[76],{"name":77,"class":78},"Icahn School of Medicine at Mount Sinai","OTHER","100313213",false,"NCT03357536","Genetic Susceptibility to Listeriosis","Genetic Susceptibility to Listeriosis - Listeria-GEN","Listeria-GEN","Inclusion Criteria for patients with Listeriosis :\n\n* Microbiologically documented Listeriosis (either a severe form of listeriosis, or an atypical form of listeriosis, or less than 40 years old and without any co-morbidity identified)\n* Affiliated or beneficiary of a social security system\n* Informed and written consent\n\nInclusion Criteria for volunteers related to patients with Listeriosis (after identifying a genetic susceptibility in the patient with Listeriosis) :\n\n* defined as father, mother, brother (s), sister (s), child (ren), grandparent (s), uncle (s), aunt (s), cousin (s), nephew (s), niece (s).\n* Affiliated or beneficiary of a social security system\n* Informed and written consent\n\nExclusion Criteria for volunteers related to patients with Listeriosis:\n\n* Inability to consent",true,"ALL",{"count":89,"type":90},100,"ESTIMATED","INTERVENTIONAL",[93],"NA","Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and \u002F or patients with comorbidities, with a deficit of innate or cellular immunity. Pregnancy is also a risk factor.\n\nThe Multicentric Observational NAtional Analysis of Listeriosis and Listeria (MONALISA) is an ongoing national case-control prospective study on listeriosis implemented since 2009 to study risk and prognosis factors for listeriosis. In this cohort, which enrolled 902 patients on 1 August 2014, 7% of patients with neurolisteriosis are under 40 years of age and have no identified risk factor. Genetic susceptibility is suspected in these patients. Genetic susceptibility could also explain the inconstant development of a neurolisteriosis or fetal infection, as well as the particular severity of some infections (death, foetal loss, neurological sequelae).\n\nThe aim of the study is to identify genetic susceptibility to Listeriosis.",[96],"Listeriosis","2025-09-18",{"date":99,"type":100},"2025-09-19","ACTUAL",{"date":102,"type":100},"2017-11-28",{"date":104,"type":90},"2027-11-30",{"name":5,"class":6},1]