[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100416102":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":33,"responsibleParty":50,"collaborators":10,"id":52,"slug":10,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Controls",null,"This research aims to recruit only adult volunteers that have taken part of the Gene \\& Health program. We will focus on two groups: individuals presenting the polymorphisms of interest and individuals without the genetic variants in the genes of interest, which will be used as matched controls. Eligible individuals will consent to donate blood samples for this study, in addition to consent access to their medical and health records.",[13],"Procedure: Blood Donation",{"label":15,"type":10,"description":11,"interventionNames":16},"Cases",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Blood Donation","The blood donation will take place at the Gene \\& Health clinical assessment centre facilities. A trained member from Gene \\& Health program will be responsible for taking the blood samples.",[15,9],[24],{"name":25,"affiliation":5,"role":26},"Jesmond Dalli, Professor","STUDY_DIRECTOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Esteban A Gomez Cifuentes, PhD student","CONTACT","+447741093970","e.a.g.c.cifuentes@qmul.ac.uk",[34],{"facility":5,"status":35,"city":36,"state":10,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","London","EC1M 6BQ","United Kingdom",{"type":40,"coordinates":41},"Point",[42,43],-0.12574,51.50853,{"lat":43,"lon":42},[46,47],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Esteban A Gomez Cifuentes, PhD Student","PRINCIPAL_INVESTIGATOR",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100416102",false,"NCT04698291","Genetic Variants and Regulation of Specialized Pro-resolving Mediator","Identifying the Effect of Genetic Variants on Specialized Pro-resolving Mediators and Their Association With Chronic Inflammatory Conditions","Inclusion Criteria:\n\n* Current volunteer of the Genes \\& Health program with (test) or without (control) relevant genetic mutations. Genes \\& Health is a huge long-term study of 100,000 people of Bangladeshi and Pakistani origin focuses to link genes with health records and to study disease and treatments. When a volunteer participates in this program, they agree to the possibility to be invited for further studies. Gene \\& Health program invites volunteers to take part in two regions of the UK: East London and Bradford.\n\nExclusion Criteria:\n\n1. Volunteer that has not had their genome sequenced after taking part in Stage 1 of Genes \\& Health program.\n2. Volunteer with significant genetically inherited conditions.\n3. Any abnormality or pre-existing disease which, in the opinion of the investigator, might either expose the subject to risk, or influence the validity of the results.\n4. Volunteer that went under surgery and are recovering.\n5. Participation in a clinical study of a new chemical entity, biological product or a prescription medicine, or loss of more than 400 mL blood, within the previous 3 months.\n6. Presence or history of drug or alcohol abuse.",true,"ALL","18 Years",{"count":62,"type":63},200,"ESTIMATED","OBSERVATIONAL","Inflammation is the way that the body reacts against infection, injury or illness. An uncontrolled inflammatory response can lead to the development of inflammatory diseases, such as rheumatoid arthritis and cardiovascular conditions. Recent studies have shown that inflammation is a regulated process coordinated by a group of molecules known as specialized pro-resolving mediator (SPM). These molecules are produced by enzymes via the enzymatic conversion of essential fatty acids; whereas their biological actions are mediated by proteins expressed on the surface of cells known as receptors.\n\nGiven the central role that pro-resolving mediators play in regulating the immune response, the aim of this study is to investigate whether there are genetic variants (mutations) in genes encoding for enzymes and receptors involved in the biology of these molecules and to determine how these mutations affect SPM's activity or function.\n\nFindings made as part of these studies will help shed light into mechanism influencing disease onset and\u002For progression and potentially enhance the discovery of new and more effective treatments.",[67,68,69],"Healthy","Inflammatory Disease","Cardiovascular Diseases","2026-02-03",{"date":72,"type":73},"2026-02-05","ACTUAL",{"date":75,"type":73},"2021-05-06",{"date":77,"type":63},"2027-12-08",{"name":5,"class":6},1]