[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100139372":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":24,"locations":34,"responsibleParty":51,"collaborators":10,"id":54,"slug":10,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Shanghai Jiao Tong University School of Medicine","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy lean control group",null,"The healthy lean controls consisted of age-, sex- and geography-matched young volunteers, or \"golden standard\" lean controls from China Cardiometabolic Disease and Cancer Cohort Study (4C Study).\n\nHealthy volunteers:\n\n1. BMI:18.5-22.9kg\u002Fm2;\n2. Age:14-30 years old;\n3. To be proved normal by the examinations of liver and kidney function,blood lipids profile,FBG, PBG, fasting insulin and HbA1c.\n\nControls from 4C Study:\n\n1. 17.0≤BMI≤23.0kg\u002Fm2 and waist circumference \\\u003C85cm for males and \\\u003C80cm for females;\n2. 1.8≤LDL-c≤3.4mmol\u002Fl;\n3. FBG\\\u003C6.1, PBG\\\u003C7.8;\n4. HOMA-IR\\\u003C2.5;\n5. BP \\\u003C140\u002F90mmHg;\n6. eGFR\\>60mL\u002F(min·1.73 m2), ALT\\\u003C40IU\u002FL, AST\\\u003C40IU\u002FL;\n7. Excluding the history of hyperthyroidism, digestive system diseases, malignant tumors, infectious diseases (hepatitis B) and other systemic wasting diseases; Severe dysfunction of heart, lung and kidney;\n8. Not using antihypertensive, hypoglycemic and lipid-lowering drugs；\n9. No history of smoking.",{"label":13,"type":10,"description":14,"interventionNames":10},"obesity group","1. BMI ≥30kg\u002Fm2;\n2. Age:14-30 years old; obesity group 4000, lean healthy control group 4000",[16,19,22],{"name":17,"affiliation":5,"role":18},"Guang Ning, MD.PhD","STUDY_CHAIR",{"name":20,"affiliation":5,"role":21},"Jie Hong, MD","PRINCIPAL_INVESTIGATOR",{"name":23,"affiliation":5,"role":21},"Jiqiu Wang, MD.PhD",[25,30],{"name":17,"role":26,"phone":27,"phoneExt":28,"email":29},"CONTACT","86-21-64370045","665340","guangning@medmail.com.cn",{"name":31,"role":26,"phone":27,"phoneExt":32,"email":33},"Jie Hong, PhD","665345","hongjie13d@hotmail.com",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Shanghai","Shanghai Municipality","200025","China",{"type":42,"coordinates":43},"Point",[44,45],121.45806,31.22222,{"lat":45,"lon":44},[48,49,50],{"name":17,"role":26,"phone":27,"phoneExt":28,"email":29},{"name":31,"role":26,"phone":27,"phoneExt":32,"email":33},{"name":17,"role":21,"phone":10,"phoneExt":10,"email":10},{"type":21,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Guang Ning","Director","100139372",false,"NCT01084967","Genetics of Obesity in Chinese Youngs","Study of Clinical Characteristics and Genetic Susceptibility in Chinese Obese Youngs","GOCY","Inclusion Criteria:\n\n* body mass index (BMI)≥ 30kg\u002Fm2\n* predominantly east China to minimize population stratification\n* willing and able to provide informed consent\n\nExclusion Criteria:\n\n* pregnancy\u002Flactation\n* Cushing syndrome\n* Hypothyroidism\n* obesity caused by pituitary and hypothalamic lesions\n* drug related obesity\n* history of major psychiatric illness",true,"ALL","14 Years","30 Years",{"count":66,"type":67},8000,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.",[71,72],"Obesity","Metabolic Syndrome",[74,75,76,77],"obesity","metabolic syndrome","genetic risk markers","copy number variation","2026-05-07",{"date":80,"type":81},"2026-05-12","ACTUAL",{"date":83,"type":10},"2009-03",{"date":85,"type":67},"2030-04",{"name":5,"class":6},1]