[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626236":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":13,"interventions":19,"overallOfficials":23,"centralContacts":28,"locations":36,"responsibleParty":271,"collaborators":273,"id":282,"slug":13,"hasResults":283,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":286,"eligibilityCriteria":287,"healthyVolunteers":283,"sex":288,"minAge":289,"maxAge":13,"enrollmentInfo":290,"targetDuration":293,"studyType":294,"phases":13,"briefSummary":295,"conditions":296,"keywords":298,"overallStatus":39,"whyStopped":13,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":315},{"fullName":5,"class":6},"RWTH Aachen University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"The primary objective is the development of a registry to collect longitudinal data on patients with cognitive impairment and dementia with fluid biomarkers in Germany.","This will allow to evaluate the current diagnostic and treatment behavior and assess the natural history of a cohort of patients with SCD, MCI or early dementia with fluid and\u002For imaging biomarkers.\n\nThe data collected on biomarkers and risk factors will help to differentiate e.g. patients with Alzheimer's dementia from patients with dementia of other etiology and to optimize diagnosis, management and care in a real-life environment.","This is an open-ended prospective registry. Data is collected during a baseline visit. Follow-up visits are conducted on an annual basis (1 year ±3 months) for as long as possible for each patient.",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","The aim of the German Dementia Registry is to prospectively collect longitudinal real-world data on all consenting patients diagnosed in clinical routine with Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), and early dementia of different etiologies in Germany, independent of their actual treatment regimen. For this purpose, an online platform will be provided.\n\nData are collected during patient visits and items for data collection are aligned with diagnostic\u002Ftreatment guidelines and clinical procedures. The disease specific registry will be conducted to prospectively follow the natural course of dementia and to differentiate e.g. patients with Alzheimer's dementia from patients with dementia of other etiology.\n\nThe data collected will provide prospective and longitudinal data demonstrating the natural course of disease and the current diagnostic and treatment behavior in clinical routine in the German healthcare system. Prospective monitoring of dementia patients is expected to lead to a better understanding of the natural history of dementia and the changes in biomarker values within different etiologies of dementia. This can help to improve and adapt the early diagnostic criteria regarding biomarkers and real-world data for patients on newly approved treatments (e.g. amyloid antibodies).","This registry will be conducted in adult patients with a diagnosis of SCD, MCI or early dementia of different etiology and existing biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42\u002Famyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.",[20],{"type":6,"name":21,"description":22,"armGroupLabels":13,"otherNames":13},"This is a registry.","This is an observational study; no treatments are carried out within the scope of the registry. The usual treatment\u002Fmedication of patients is merely documented. Additionally, using a variety of questionnaires and tests, data is generated from participants in relation to early dementia.",[24],{"name":25,"affiliation":26,"role":27},"Jörg B. Schulz, Prof. Dr.","Department of Neurology, RWTH Aachen University Hospital","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":13,"email":33},"Prof. Dr. Jörg B. Schulz, MD","CONTACT","+49 241 80-89600","NE-Wissenschaftsmanagement@ukaachen.de",{"name":35,"role":31,"phone":13,"phoneExt":13,"email":13},"Prof. Dr. Kathrin Reetz, MD",[37,51,60,69,78,88,98,107,117,123,133,143,153,167,177,186,196,205,215,225,235,245,255,261],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":13},"Heidelberg University Hospital","RECRUITING","Heidelberg","Baden-Wurttemberg","69120","Germany","DE",{"type":46,"coordinates":47},"Point",[48,49],8.69079,49.40768,{"lat":49,"lon":48},{"facility":52,"status":39,"city":53,"state":41,"zip":54,"country":43,"countryCode":44,"cosmosGeoPoint":55,"geoPoint":59,"contacts":13},"ZI Mannheim","Mannheim","68159",{"type":46,"coordinates":56},[57,58],8.46694,49.4891,{"lat":58,"lon":57},{"facility":61,"status":39,"city":62,"state":41,"zip":63,"country":43,"countryCode":44,"cosmosGeoPoint":64,"geoPoint":68,"contacts":13},"University Hospital Tübingen","Tübingen","72076",{"type":46,"coordinates":65},[66,67],9.05222,48.52266,{"lat":67,"lon":66},{"facility":70,"status":39,"city":71,"state":41,"zip":72,"country":43,"countryCode":44,"cosmosGeoPoint":73,"geoPoint":77,"contacts":13},"Ulm University Hospital","Ulm","89070",{"type":46,"coordinates":74},[75,76],9.99155,48.39841,{"lat":76,"lon":75},{"facility":79,"status":39,"city":80,"state":81,"zip":82,"country":43,"countryCode":44,"cosmosGeoPoint":83,"geoPoint":87,"contacts":13},"Universitätsklinikum Erlangen","Erlangen","Bavaria","91054",{"type":46,"coordinates":84},[85,86],11.00783,49.59099,{"lat":86,"lon":85},{"facility":89,"status":39,"city":90,"state":91,"zip":92,"country":43,"countryCode":44,"cosmosGeoPoint":93,"geoPoint":97,"contacts":13},"Klinikum Frankfurt (Oder)","Frankfurt (Oder)","Brandenburg","15236",{"type":46,"coordinates":94},[95,96],14.55062,52.34714,{"lat":96,"lon":95},{"facility":99,"status":39,"city":100,"state":91,"zip":101,"country":43,"countryCode":44,"cosmosGeoPoint":102,"geoPoint":106,"contacts":13},"Immanuel Klinik Rüdersdorf","Rüdersdorf","15562",{"type":46,"coordinates":103},[104,105],13.78631,52.46927,{"lat":105,"lon":104},{"facility":108,"status":39,"city":109,"state":110,"zip":111,"country":43,"countryCode":44,"cosmosGeoPoint":112,"geoPoint":116,"contacts":13},"Medical Center Hamburg-Eppendorf","Hamburg","Free and Hanseatic City of Hamburg","20251",{"type":46,"coordinates":113},[114,115],9.99302,53.55073,{"lat":115,"lon":114},{"facility":118,"status":39,"city":109,"state":110,"zip":119,"country":43,"countryCode":44,"cosmosGeoPoint":120,"geoPoint":122,"contacts":13},"Asklepios Klinik Nord","22419",{"type":46,"coordinates":121},[114,115],{"lat":115,"lon":114},{"facility":124,"status":39,"city":125,"state":126,"zip":127,"country":43,"countryCode":44,"cosmosGeoPoint":128,"geoPoint":132,"contacts":13},"Klinikum Bremen-Ost","Bremen","Free Hanseatic City of Bremen","28325",{"type":46,"coordinates":129},[130,131],8.80717,53.07582,{"lat":131,"lon":130},{"facility":134,"status":39,"city":135,"state":136,"zip":137,"country":43,"countryCode":44,"cosmosGeoPoint":138,"geoPoint":142,"contacts":13},"University Medical Center Göttingen","Göttingen","Lower Saxony","37075",{"type":46,"coordinates":139},[140,141],9.93228,51.53443,{"lat":141,"lon":140},{"facility":144,"status":39,"city":145,"state":146,"zip":147,"country":43,"countryCode":44,"cosmosGeoPoint":148,"geoPoint":152,"contacts":13},"Greifswald University Medicine","Greifswald","Mecklenburg-Vorpommern","17489",{"type":46,"coordinates":149},[150,151],13.40244,54.08905,{"lat":151,"lon":150},{"facility":154,"status":39,"city":155,"state":156,"zip":157,"country":43,"countryCode":44,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"RWTH Aachen University Hospital","Aachen","North Rhine-Westphalia","52074",{"type":46,"coordinates":159},[160,161],6.08342,50.77664,{"lat":161,"lon":160},[164],{"name":165,"role":31,"phone":166,"phoneExt":13,"email":33},"Prof. Dr. Jörg B. Schulz","+49 0241 80-89600",{"facility":168,"status":169,"city":170,"state":156,"zip":171,"country":43,"countryCode":44,"cosmosGeoPoint":172,"geoPoint":176,"contacts":13},"University Hospital Cologne","NOT_YET_RECRUITING","Cologne","50937",{"type":46,"coordinates":173},[174,175],6.95,50.93333,{"lat":175,"lon":174},{"facility":178,"status":39,"city":179,"state":156,"zip":180,"country":43,"countryCode":44,"cosmosGeoPoint":181,"geoPoint":185,"contacts":13},"University Hospital Essen","Essen","45147",{"type":46,"coordinates":182},[183,184],7.01228,51.45657,{"lat":184,"lon":183},{"facility":187,"status":39,"city":188,"state":189,"zip":190,"country":43,"countryCode":44,"cosmosGeoPoint":191,"geoPoint":195,"contacts":13},"Pfalzklinikum Klingenmünster","Klingenmünster","Rhineland-Palatinate","76889",{"type":46,"coordinates":192},[193,194],8.01861,49.14056,{"lat":194,"lon":193},{"facility":197,"status":169,"city":198,"state":189,"zip":199,"country":43,"countryCode":44,"cosmosGeoPoint":200,"geoPoint":204,"contacts":13},"University Medical Center Mainz","Mainz","55131",{"type":46,"coordinates":201},[202,203],8.28008,49.98185,{"lat":203,"lon":202},{"facility":206,"status":39,"city":207,"state":208,"zip":209,"country":43,"countryCode":44,"cosmosGeoPoint":210,"geoPoint":214,"contacts":13},"Saarland University Medical Center","Homburg","Saarland","66421",{"type":46,"coordinates":211},[212,213],7.33867,49.32637,{"lat":213,"lon":212},{"facility":216,"status":39,"city":217,"state":218,"zip":219,"country":43,"countryCode":44,"cosmosGeoPoint":220,"geoPoint":224,"contacts":13},"University of Leipzig Medical Center","Leipzig","Saxony","04103",{"type":46,"coordinates":221},[222,223],12.37129,51.33962,{"lat":223,"lon":222},{"facility":226,"status":39,"city":227,"state":228,"zip":229,"country":43,"countryCode":44,"cosmosGeoPoint":230,"geoPoint":234,"contacts":13},"Madical Faculty University Hospital Magdeburg","Magdeburg","Saxony-Anhalt","39120",{"type":46,"coordinates":231},[232,233],11.63189,52.13129,{"lat":233,"lon":232},{"facility":236,"status":39,"city":237,"state":238,"zip":239,"country":43,"countryCode":44,"cosmosGeoPoint":240,"geoPoint":244,"contacts":13},"University Hospital Schleswig-Holstein","Kiel","Schleswig-Holstein","24105",{"type":46,"coordinates":241},[242,243],10.13489,54.32133,{"lat":243,"lon":242},{"facility":246,"status":39,"city":247,"state":248,"zip":249,"country":43,"countryCode":44,"cosmosGeoPoint":250,"geoPoint":254,"contacts":13},"Charité - Universitätsmedizin Berlin","Berlin","State of Berlin","10117",{"type":46,"coordinates":251},[252,253],13.41053,52.52437,{"lat":253,"lon":252},{"facility":256,"status":39,"city":247,"state":248,"zip":257,"country":43,"countryCode":44,"cosmosGeoPoint":258,"geoPoint":260,"contacts":13},"Charité Campus Benjamin Franklin","12203",{"type":46,"coordinates":259},[252,253],{"lat":253,"lon":252},{"facility":262,"status":169,"city":263,"state":264,"zip":265,"country":43,"countryCode":44,"cosmosGeoPoint":266,"geoPoint":270,"contacts":13},"University Hospital Jena","Jena","Thuringia","07747",{"type":46,"coordinates":267},[268,269],11.5899,50.92878,{"lat":269,"lon":268},{"type":27,"investigatorFullName":30,"investigatorTitle":272,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Prof. Dr. Jörg B. Schulz, MD, Head of the Department of Neurology at the University Hospital Aachen and Project Manager",[274,277,280],{"name":275,"class":276},"Eisai GmbH","INDUSTRY",{"name":278,"class":279},"Lilly Deutschland GmbH Germany","UNKNOWN",{"name":281,"class":276},"Biogen","100626236",false,"NCT07433010","German Dementia Registry","DemReg","Inclusion Criteria:\n\nInclusion Criteria for Patient:\n\n* Ability of the participant and\u002For his\u002Fher legally authorized representative (e.g., spouse or legal guardian), as appropriate and applicable, to understand the purpose and risks of the register and provide signed and dated informed consent and authorization to use protected health information (PHI) in accordance with national and local privacy regulations.\n* Participating patients must have a diagnosis of SCD, MCI or early dementia of different etiology (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy-Body Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Normal Pressure Hydrocephalus, Major Depression; Vascular Dementia; TDP-43 associated limbic encephalopathy (LATE), Mixed Dementia AD + VaD, Prion-Associated Dementia) together with biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42\u002Famyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.\n* At least 18 years of age.\n\nInclusion Criteria for family member:\n\n* At least 18 years of age.\n* Patient was included in the registry\n* Family member is strongly involved to the patient's life according to the patient's statement\n* Ability of the participant, as appropriate and applicable, to understand the purpose and risks of the register\n\nExclusion Criteria:\n\nExclusion Criteria for Patient:\n\n* Unwilling to provide informed consent.\n* No available biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42\u002Famyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.\n\nExclusion Criteria for family member:\n\n* Unable or unwilling to provide informed consent.","ALL","18 Years",{"count":291,"type":292},5000,"ESTIMATED","20 Years","OBSERVATIONAL","The German Dementia Registry (DEMREG) is a large-scale national prospective biomarker-based study for cognitive impairment and dementia, providing an integrated clinical research platform for research studies.",[297],"Dementia Disorder",[299,300,301,302,303,304,305],"Dementia","Registry","Biomarkers","Neurodegeneration","Natural history","Treatment","Mild Cognitive Impairment","2026-02-18",{"date":308,"type":309},"2026-02-25","ACTUAL",{"date":311,"type":309},"2022-05-16",{"date":313,"type":292},"2099-12",{"name":5,"class":6},24]