Glofitamab in Real Life

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorThe Lymphoma Academic Research Organisation

About this trial

To date, more than 300 patients have been treated with Glofitamab in the Expanded Access Programme (EAP) in France. In this study, it is proposed to perform a retrospective analysis of some of these patients. The aim is to describe the efficacy and safety of Glofitamab in the largest reported real-world cohort, with an expected median follow-up of more than 9 months. Particular focus will be given to the relapsed or refractory chimeric antigen receptors-T (CAR-T) population to confirm the response rates (CRR: 35-39%) of Glofitamab in this population and to assess the optimal timing of therapy initiation \[8, 15\].

Eligibility criteria

Qualifiers

patient enrolled in the French Glofitamab EAP for R/R DLBCL before 2024 November 1st, 2024

patient who received at least Obinutuzumab pretreatment and one infusion of Glofitamab

adult patient

patient who is informed of the study and who did not oppose to their data collection

Disqualifiers

none

Trial design

Treatments tested in this trial

  • Glofitamab

Treatment groups

250 Participants
are divided into 1 treatment group

Locations

30
CH Victor Dupouy95100, Argenteuil France
CH d'Avignon - Hôpital Henri Dufaut84000, Avignon France
CH de la Côte Basque Bayonne France
CHRU Besançon - Hôpital Minjoz Besançon France

Sponsors and collaborators

The Lymphoma Academic Research Organisation

Lead sponsor