This clinical trial aims to determine whether perioperative goal-directed nutritional therapy can prevent postoperative pulmonary and other major complications in malnourished esophageal squamous cell cancer patients. Its main question is whether individualized nutritional therapy can improve short-term surgical outcomes and long-term prognosis. Researchers will compare goal-directed and conventional nutritional therapy to identify differences in morbidities and survival.
Aged 18-80 years old;
ECOG PS 0~1;
NRS 2002 score ≥3;
Malnutrition diagnosed according to the GLIM criteria;
NRS 2002 score < 3;
Upfront surgery without neoadjuvant treatment;
Any comorbidity interferes with the digestion and absorption of ORAL IMPACT®;
Receiving any other nutritional support during the study;
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Lead sponsor