[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632645":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":49,"collaborators":51,"id":53,"slug":10,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"DSA-",null,"Lung transplant patients who didn't develop donor specific antibodies",{"label":13,"type":10,"description":14,"interventionNames":10},"DSA+","Lung transplant patients who developed donor specific antibodies",[16],{"name":17,"affiliation":18,"role":19},"Muhtadi H Alnababteh, M.D.","National Heart, Lung, and Blood Institute (NHLBI)","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Andrew G Keel, C.R.N.P.","CONTACT","(301) 648-5674","andrew.keel@nih.gov",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"(301) 827-3272","muhtadi.alnababteh@nih.gov",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States",{"type":38,"coordinates":39},"Point",[40,41],-77.10026,38.98067,{"lat":41,"lon":40},[44],{"name":45,"role":23,"phone":46,"phoneExt":47,"email":48},"NIH Clinical Center Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[52],{"name":5,"class":6},"100632645",false,"NCT07516379","GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Stated willingness to comply with study procedures and availability for the duration of the study.\n2. Male or female, aged 18 - 75 years of age.\n3. Have progressive lung disease or undergone or being evaluated for lung transplantation.\n4. Ability of subjects to understand the informed consent document.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1\\. Pregnancy or lactation","ALL","18 Years","75 Years",{"count":62,"type":63},100,"ESTIMATED","OBSERVATIONAL","Background:\n\nLung transplants can save lives, but the procedure has risks. Some people develop donor-specific antibodies (DSA) after the procedure-that is, their bodies create proteins that treat the new lungs as foreign and mount an immune response against them. This is called rejection. But not everyone who has a transplant develops DSA, and not everyone who has DSA develops rejection. Researchers want to understand why.\n\nObjective:\n\nTo collect data to try to find out why some people develop rejection after lung transplants while others do not.\n\nEligibility:\n\nPeople aged 18 to 75 years who have progressive lung disease or undergone or may undergo a lung transplant.\n\nDesign:\n\nParticipants will have clinic visits every 3 to 6 months for up to 4 years. Some visits might require an overnight stay.\n\nEach visit will include multiple tests and procedures:\n\nPhysical exam with blood and urine tests. Some blood will be used for genetic testing.\n\nImaging scans. Participants will have 2 types of scan to get images of their lungs. For one, they will have a contrast agent given through a tube inserted into a vein.\n\nSix-minute walk test. Participants will walk back and forth in a hallway at their own pace. Researchers will check on how their body responds.\n\nLung function test. Participants will breathe into a tube connected to a machine.\n\nTwo other tests are optional:\n\nBronchoscopy with washings (lavage). A long tube with a light will be threaded down through the participant s nose or mouth and into their lungs.\n\nEndomicroscopy. During the bronchoscopy a tiny camera may be used to take pictures inside the lungs.\n\n...",[67,68,69],"Lung Transplant","End Stage Lung Disease","Rejection",[67,69],"2026-06-10",{"date":73,"type":74},"2026-06-11","ACTUAL",{"date":76,"type":74},"2026-05-11",{"date":78,"type":63},"2032-03-27",{"name":18,"class":6},1]