[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100407843":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":36,"responsibleParty":54,"collaborators":23,"id":56,"slug":23,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":23,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":23,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":39,"whyStopped":23,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Roux-en-y gastric bypass subjects","EXPERIMENTAL","Inclusion Criteria: Age 18-70. Participants pre-Roux-en-y gastric bypass (RYGB) who are approved and planned for Roux-en-y gastric bypass surgery in the Bariatric Surgery Center at the UCM.\n\nExclusion Criteria: Patients with primary kidney diseases, kidney stone disease, or kidney impairment (eGFR \\\u003C 90). Patients with known bladder voiding problems.\n\nParticipants will complete a diet record and a 24-hour urine collection both before and after surgery.\n\nParticipants will consume a 3 day fixed diet and present to the clinical research center for timed blood and urine draws. They will do this before and twice after (1 month and 1 year) surgery.",[13],"Other: Special diet",{"label":15,"type":10,"description":16,"interventionNames":17},"Sleeve gastrectomy subjects","Inclusion Criteria: Age 18-70. Participants pre-sleeve gastrectomy who are approved and sleeve gastrectomy in the Bariatric Surgery Center at the UCM.\n\nExclusion Criteria: Patients with primary kidney diseases, kidney stone disease, or kidney impairment (eGFR \\\u003C 90). Patients with known bladder voiding problems.\n\nParticipants will complete a diet record and a 24-hour urine collection both before and after surgery.\n\nParticipants will consume a 3 day fixed diet and present to the clinical research center for timed blood and urine draws. They will do this before and twice after (1 month and 1 year) surgery.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Special diet","The research clinic will provide subjects with a special diet for six days. After six days of isocaloric sodium, calcium and fluid intake, the study team will analyze three sequential 24-hour urine compositions including supersaturation of calcium oxalate, calcium, and urine volume, as well as stool collections. We will also evaluate components of 24-hour urine composition, specifically supersaturation, and the microbial contributions to urinary composition in 72-hour stool samples simultaneously collected using shot-gun metagenomic sequencing in men and women 1 year after surgery.",[9,15],null,[25],{"name":26,"affiliation":5,"role":27},"Prochaska Megan, MD","PRINCIPAL_INVESTIGATOR",[29,35],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Megan Prochaska","CONTACT","(773) 702-1000","45488","mprocha2@medicine.bsd.uchicago.edu",{"name":26,"role":31,"phone":32,"phoneExt":33,"email":34},[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University of Chicago Medical Center","RECRUITING","Chicago","Illinois","60637","United States",{"type":45,"coordinates":46},"Point",[47,48],-87.65005,41.85003,{"lat":48,"lon":47},[51],{"name":52,"role":31,"phone":53,"phoneExt":33,"email":34},"Megan Prochaska, MD","773-702-1000",{"type":55,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100407843",false,"NCT04590690","Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery","Inclusion Criteria:\n\n* Participants without history of stone disease, family history of stone disease\n* Participants pre-bariatric surgery who are approved and planned for surgery in the Bariatric Surgery Center at University of Chicago Medicine.\n\nExclusion Criteria:\n\n* Patients with primary renal diseases or renal impairment (eGFR \\\u003C 90)\n* Patients with known bladder voiding problems\n* Patients with 25-vitamine D deficiency, as defined by level \\\u003C 25ng\u002FmL","ALL","18 Years","130 Years",{"count":65,"type":66},28,"ESTIMATED","INTERVENTIONAL",[69],"NA","This is a single-center study that aims to better understand how diet and sex affect the risk of kidney stones in people who have had gastric bypass surgery. Subjects will be asked to follow a special (clinic-provided) diet for six days and come to a research clinic for 3 study visits.",[72],"Bariatric Surgery Candidate",[74,75],"bariatric surgery","kidney stones","2026-05-08",{"date":78,"type":79},"2026-05-11","ACTUAL",{"date":81,"type":79},"2020-11-01",{"date":83,"type":66},"2027-05-01",{"name":5,"class":6},1]