[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623790":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":57,"id":61,"slug":26,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Reading","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prebiotic (powder)","EXPERIMENTAL","Children will consume two (one in the morning and one in the evening) 2.5g of prebiotic sachets a day (mixed with food and drink).",[13],"Dietary Supplement: Prebiotic powder",{"label":15,"type":16,"description":17,"interventionNames":18},"Matched placebo (powder)","PLACEBO_COMPARATOR","Children will consume two (one in the morning and one in the evening) 2.5g of placebo sachets a day (mixed with food and drink).",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Prebiotic powder","5g of prebiotic fibre",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","5g of placebo",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Piril Hepsomali, PhD","CONTACT","+44 118 378 5818","p.hepsomali@reading.ac.uk",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of Reading, School of Psychology and Clinical Languages","RECRUITING","Reading","Berkshire","RG6 6BZ","United Kingdom",{"type":46,"coordinates":47},"Point",[48,49],-0.97113,51.45625,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Piril Hepsomali","Principle Investigator",[58],{"name":59,"class":60},"Beneo GmbH","INDUSTRY","100623790",false,"NCT07401212","GUTLINK4KIDS Intervention","The Impact of Chronic Consumption of Prebiotics on Cognitive and Affective Outcomes, Gut Microbiome Diversity and Composition in 3-5 Year Olds: a Double-blind Placebo-controlled, Parallel-groups Randomised Controlled Trial","GUTLINK4KIDS","Inclusion Criteria:\n\n* Parents (18 years and over) of generally healthy children aged 3-5-years-old (36-71 months) with lower dietary fibre intake than the recommended daily amount (10.4g\u002Fday in 18-47-month-olds and less than 12.6g\u002Fday in 48-60-month-olds).\n\nExclusion Criteria:\n\n* Children with a significant acute or chronic co-existing illness (including inflammatory bowel disease, functional gastrointestinal disorders, coeliac disease etc, neurodevelopmental, immunological, psychiatric, or metabolic disorders.\n* Children who have taken any pre\u002Fprobiotic supplements or antibiotic treatment within the 4 weeks prior to enrolment.\n* Children with food allergies and intolerances",true,"ALL","3 Years","5 Years",{"count":73,"type":74},106,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study aims to investigate the chronic effects of prebiotic consumption on cognitive, behavioural and gut microbiome outcomes in children aged 3-5 years.",[80,81,82,83],"Temperament","Sleep","Cognition","Emotion Regulation",[85,86,87,88,89,90,91,92],"prebiotics","emotion regulation","gut microbiome diversity","children","relative abundance","sleep","internalising symptoms","externalising symptoms","2026-04-27",{"date":95,"type":96},"2026-04-28","ACTUAL",{"date":98,"type":96},"2026-03-02",{"date":100,"type":74},"2027-02-01",{"name":5,"class":6},1]