[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100512984":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":36,"studyPopulation":25,"armGroups":37,"interventions":61,"overallOfficials":25,"centralContacts":67,"locations":73,"responsibleParty":90,"collaborators":92,"id":95,"slug":25,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":25,"eligibilityCriteria":100,"healthyVolunteers":101,"sex":102,"minAge":103,"maxAge":25,"enrollmentInfo":104,"targetDuration":25,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":25,"overallStatus":75,"whyStopped":25,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University of Manitoba","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"change of functional connectivity","Changes in seed-based connectivity originating from the targeted brain regions immediately after the brain stimulation","0-11 minutes after the stimulation contrasting baseline (before stimulation)",[14,18,22],{"measure":15,"description":16,"timeFrame":17},"change of cerebral blood flow","Changes in Cerebral Blood Flow (estimated using pseudo continuous arterial spin labeling )","12-16 minutes after the stimulation contrasting baseline (before stimulation)",{"measure":19,"description":20,"timeFrame":21},"Toronto Mindfulness Scale (curiosity)","mindfulness scale for curiosity. min: 0, max: 30. Higher score means higher curiosity-mindfulness.","Baseline, then within 1-2 hours from stimulation",{"measure":23,"description":24,"timeFrame":21},"Toronto Mindfulness Scale (decentering)","mindfulness scale for decentering. min: 0, max: 35. Higher score means higher decentering-mindfulness.",null,{"allocation":27,"interventionModel":28,"interventionModelDescription":29,"primaryPurpose":30,"observationalModel":25,"timePerspective":25,"maskingInfo":31},"RANDOMIZED","PARALLEL","4 active treatment groups + 1 inactive treatment group","BASIC_SCIENCE",{"masking":32,"maskingDescription":33,"whoMasked":34},"SINGLE","Randomization will happen after baseline assessment. After-intervention assessment will only consist of self-report and computerized assessment. Participants will not aware of the treatment group that they were assigned to.",[35],"PARTICIPANT","Normal healthy individuals will be recruited and undergo a standardized neuropsychological assessment (ANAM, MoCA, BDI-II, ToMS, and MAAS) and magnetic resonance imaging (MRI). During MRI, HD-tDCS will be applied. Four different stimulation targets will be investigated, and subjects will be randomly assigned for each target groups or sham group. After HD-tDCS\u002FMRI session, subjects will be re-assessed with standardized neuropsychological tests.",[38,44,48,52,56],{"label":39,"type":40,"description":41,"interventionNames":42},"left DLPFC stimulation","EXPERIMENTAL","HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the left dorsolateral prefrontal cortex (DLPFC; x=-44, y=10, z=30) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes.",[43],"Device: high definition transcranial direct current stimulation (HD-tDCS)",{"label":45,"type":40,"description":46,"interventionNames":47},"right DLPFC stimulation","HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the right dorsolateral prefrontal cortex (DLPFC; x=+42, y=+14, z=+30) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes.",[43],{"label":49,"type":40,"description":50,"interventionNames":51},"left IPL stimulation","HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the left intraparietal lobe (IPL; x=-50, y=-36, z=+42) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes.",[43],{"label":53,"type":40,"description":54,"interventionNames":55},"VLPFC-PCC stimulation","HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the left ventrolateral prefrontal cortex (VLPFC; x=-50, y=+26, z=+8) and posterior cingulate cortex (PCC; x=1, y=-61, z=38) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes.",[43],{"label":57,"type":58,"description":59,"interventionNames":60},"Sham stimulation","SHAM_COMPARATOR","One of the above three targets will be randomly selected. The current will be applied for 30 seconds ramp-up followed by 30 seconds ramp-down.",[43],[62],{"type":63,"name":64,"description":65,"armGroupLabels":66,"otherNames":25},"DEVICE","high definition transcranial direct current stimulation (HD-tDCS)","HD-tDCS will be provided for 20 minutes for each stimulation with peak intensity of 2mA.",[57,53,39,49,45],[68],{"name":69,"role":70,"phone":71,"phoneExt":25,"email":72},"Ji Hyun Ko, PhD","CONTACT","2042930724","ji.ko@umanitoba.ca",[74],{"facility":5,"status":75,"city":76,"state":77,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"RECRUITING","Winnipeg","Manitoba","R3E 0J9","Canada","CA",{"type":82,"coordinates":83},"Point",[84,85],-97.14704,49.8844,{"lat":85,"lon":84},[88],{"name":69,"role":70,"phone":89,"phoneExt":25,"email":72},"204-318-2566",{"type":91,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[93],{"name":94,"class":6},"Natural Sciences and Engineering Research Council, Canada","100512984",false,"NCT05959551","HD-tDCS to Modulate Connectivity","Modulating Functional Brain Connectivity Using High Definition Transcranial Direct Current Stimulation (HD-tDCS)","Inclusion Criteria:\n\n\\- All other than excluded.\n\nExclusion Criteria:\n\n* History or susceptibility to any neurological or psychiatric diseases, particularly seizures\n* abnormal MRI\n* metal implants or a cardiac pacemaker\n* pregnant or breastfeeding women",true,"ALL","18 Years",{"count":105,"type":106},100,"ESTIMATED","INTERVENTIONAL",[109],"NA","The purpose of the proposed study is to broaden our understanding on the neural effects of High Definition Transcranial Direct Current Stimulation (HD-tDCS) so that its clinical effects can be further improved.",[112],"Electricity; Effects","2026-04-27",{"date":115,"type":116},"2026-05-01","ACTUAL",{"date":118,"type":116},"2023-07-01",{"date":120,"type":106},"2026-08-31",{"name":5,"class":6},1]