[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100274686":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":33,"centralContacts":37,"locations":46,"responsibleParty":651,"collaborators":654,"id":657,"slug":10,"hasResults":658,"nctId":659,"briefTitle":660,"officialTitle":660,"acronym":661,"eligibilityCriteria":662,"healthyVolunteers":663,"sex":664,"minAge":665,"maxAge":666,"enrollmentInfo":667,"targetDuration":10,"studyType":670,"phases":10,"briefSummary":671,"conditions":672,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":674,"lastUpdatePostDateStruct":675,"startDateStruct":678,"completionDateStruct":10,"leadSponsor":680,"locationsCount":681},{"fullName":5,"class":6},"University College, London","OTHER",[8,12,15,18,21,24,27,30],{"label":9,"type":10,"description":11,"interventionNames":10},"Early Pre-manifest HD",null,"Participants eligible are persons who meet the following criteria:\n\n1. Are 18-75 years of age, inclusive, at the time of consent; and\n2. Do not have clinical diagnostic motor features of HD, defined as Unified Huntington's Disease Rating Scale (UHDRS) Diagnostic Confidence Score \\\u003C 4; and\n3. Have CAG expansion ≥ 40; and\n4. Have burden of pathology score, computed as (CAG - 35.5) × age, \\\u003C 250",{"label":13,"type":10,"description":14,"interventionNames":10},"Late Pre-manifest HD","Participants eligible are persons who meet the following criteria:\n\n1. Are 18-75 years of age, inclusive, at the time of consent; and\n2. Do not have clinical diagnostic motor features of HD, defined as Unified Huntington's Disease Rating Scale (UHDRS) Diagnostic Confidence Score \\\u003C 4; and\n3. Have CAG expansion ≥ 40; and\n4. Have burden of pathology score, computed as (CAG - 35.5) x age, ≥ 250",{"label":16,"type":10,"description":17,"interventionNames":10},"Early Manifest HD","Participants eligible are persons who meet the following criteria:\n\n1. Are 21-75 years of age, inclusive, at the time of consent; and\n2. Have clinical diagnostic motor features of HD, defined as UHDRS Diagnostic Confidence Score = 4; and\n3. Have CAG expansion ≥ 40; and\n4. Have Stage I or Stage II HD, defined as UHDRS Total Functional Capacity (TFC) scores between 7 and 13 inclusive",{"label":19,"type":10,"description":20,"interventionNames":10},"Moderate Manifest HD","Participants eligible are persons who meet the following criteria:\n\n1. Are 21-75 years of age, inclusive, at the time of consent; and\n2. Have clinical diagnostic motor features of HD, defined as UHDRS Diagnostic Confidence Score = 4; and\n3. Have CAG expansion ≥ 40; and\n4. Have Stage III HD, defined as UHDRS TFC scores between 3 and 6, inclusive",{"label":22,"type":10,"description":23,"interventionNames":10},"Advanced Manifest HD","Participants eligible are persons who meet the following criteria:\n\n1. Are 21-75 years of age, inclusive, at the time of consent; and\n2. Have clinical diagnostic motor features of HD, defined as UHDRS Diagnostic Confidence Score = 4; and\n3. Have CAG expansion ≥ 40; and\n4. Have Stage IV HD, defined as UHDRS TFC scores between 0 and 2, inclusive",{"label":25,"type":10,"description":26,"interventionNames":10},"Incomplete Penetrance HD","Participants eligible are persons who meet the following criteria:\n\n1. Are 18-75 years of age, inclusive, at the time of consent; and\n2. Have CAG expansion of 36-39",{"label":28,"type":10,"description":29,"interventionNames":10},"Juvenile Manifest HD","Participants eligible are persons who meet the following criteria:\n\n1. Are ≥11 years of age at the time of consent; and\n2. Have clinical diagnostic features of juvenile HD, defined as UHDRS Diagnostic Confidence Score = 4 aged ≤20 years; and\n3. Have CAG expansion ≥ 40",{"label":31,"type":10,"description":32,"interventionNames":10},"Healthy Control","Participants eligible are persons who meet the following criteria:\n\n1. Are 18-75 years of age, inclusive, at the time of consent; and\n2. Have no known family history of HD; or\n3. Have known family history of HD but have been tested for the huntingtin gene CAG expansion and are not at genetic risk for HD (CAG \\\u003C 36).",[34],{"name":35,"affiliation":5,"role":36},"Edward J Wild, MA, MB BChir, MRCP, PhD","PRINCIPAL_INVESTIGATOR",[38,42],{"name":39,"role":40,"phone":10,"phoneExt":10,"email":41},"Katarzyna Schubert, PhD","CONTACT","hdclarity-cc@enroll-hd.org",{"name":43,"role":40,"phone":44,"phoneExt":10,"email":45},"Gail Owen, PhD","+44 1273 640 688","g.owen@ucl.ac.uk",[47,69,86,103,114,131,148,160,176,191,197,214,230,248,265,280,296,312,328,338,353,371,387,397,414,425,442,457,475,492,509,518,534,550,559,575,590,606,619,635],{"facility":48,"status":49,"city":50,"state":51,"zip":10,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Cenexel","RECRUITING","Englewood","Colorado","United States",{"type":54,"coordinates":55},"Point",[56,57],-104.98776,39.64777,{"lat":57,"lon":56},[60,64,67],{"name":61,"role":40,"phone":62,"phoneExt":10,"email":63},"Jessica Crall","303-867-5473","j.crall@cenexel.com",{"name":65,"role":40,"phone":10,"phoneExt":10,"email":66},"Melanie Patton","m.patton@cenexel.com",{"name":68,"role":36,"phone":10,"phoneExt":10,"email":10},"Meagen Salinas, MD",{"facility":70,"status":49,"city":71,"state":72,"zip":73,"country":52,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Georgetown University","Washington D.C.","District of Columbia","20057",{"type":54,"coordinates":75},[76,77],-77.03637,38.89511,{"lat":77,"lon":76},[80,84],{"name":81,"role":40,"phone":82,"phoneExt":10,"email":83},"Erin Koppel","202-687-1525","ek875@georgetown.edu",{"name":85,"role":36,"phone":10,"phoneExt":10,"email":10},"Karen Anderson, MD",{"facility":87,"status":49,"city":88,"state":89,"zip":90,"country":52,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"John Hopkins University","Baltimore","Maryland","21287",{"type":54,"coordinates":92},[93,94],-76.61219,39.29038,{"lat":94,"lon":93},[97,101],{"name":98,"role":40,"phone":99,"phoneExt":10,"email":100},"Susan Robinson","410-955-1349","srobin95@jhmi.edu",{"name":102,"role":36,"phone":10,"phoneExt":10,"email":10},"Jee Bang, MPH, MD",{"facility":104,"status":105,"city":106,"state":107,"zip":108,"country":52,"cosmosGeoPoint":109,"geoPoint":113,"contacts":10},"Wake Forest University","COMPLETED","Winston-Salem","North Carolina","27109",{"type":54,"coordinates":110},[111,112],-80.24422,36.09986,{"lat":112,"lon":111},{"facility":115,"status":49,"city":116,"state":117,"zip":118,"country":52,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"Vanderbilt University Medical Center","Nashville","Tennessee","37212",{"type":54,"coordinates":120},[121,122],-86.78444,36.16589,{"lat":122,"lon":121},[125,129],{"name":126,"role":40,"phone":127,"phoneExt":10,"email":128},"Carol Wallace, RN","615-936-1007","carol.l.wallace@vumc.org",{"name":130,"role":36,"phone":10,"phoneExt":10,"email":10},"Amy Brown, MD",{"facility":132,"status":49,"city":133,"state":134,"zip":135,"country":52,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"University of Texas Health Science Center","Houston","Texas","77030",{"type":54,"coordinates":137},[138,139],-95.36327,29.76328,{"lat":139,"lon":138},[142,146],{"name":143,"role":40,"phone":144,"phoneExt":10,"email":145},"Brittany Duncan","713-486-3134","brittany.j.duncan@uth.tmc.edu",{"name":147,"role":36,"phone":10,"phoneExt":10,"email":10},"Erin Furr-Stimming",{"facility":149,"status":150,"city":151,"state":152,"zip":153,"country":154,"cosmosGeoPoint":155,"geoPoint":159,"contacts":10},"University of British Columbia, The Centre for Huntingtons Disease","ACTIVE_NOT_RECRUITING","Vancouver","British Columbia","V6T 2B5","Canada",{"type":54,"coordinates":156},[157,158],-123.11934,49.24966,{"lat":158,"lon":157},{"facility":161,"status":49,"city":162,"state":163,"zip":164,"country":154,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"The Ottawa Hospital","Ottawa","Ontario","K1Y 4E9",{"type":54,"coordinates":166},[167,168],-75.69812,45.41117,{"lat":168,"lon":167},[171,174],{"name":172,"role":40,"phone":10,"phoneExt":10,"email":173},"Jane Ding","jading@toh.ca",{"name":175,"role":36,"phone":10,"phoneExt":10,"email":10},"Tiago Mestre, Dr",{"facility":177,"status":49,"city":178,"state":163,"zip":179,"country":154,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"North York General Hospital","Toronto","M2K 1E1",{"type":54,"coordinates":181},[182,183],-79.39864,43.70643,{"lat":183,"lon":182},[186,189],{"name":187,"role":40,"phone":10,"phoneExt":10,"email":188},"Rebecca Searles","Rebecca.Searles@nygh.on.ca",{"name":190,"role":36,"phone":10,"phoneExt":10,"email":10},"Philippe Rizek, Dr",{"facility":192,"status":105,"city":178,"state":163,"zip":193,"country":154,"cosmosGeoPoint":194,"geoPoint":196,"contacts":10},"Centre for Movement Disorders","M3B 2S7",{"type":54,"coordinates":195},[182,183],{"lat":183,"lon":182},{"facility":198,"status":49,"city":199,"state":10,"zip":200,"country":201,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Centre Hospitalier Universitaire d'Angers","Angers","49000","France",{"type":54,"coordinates":203},[204,205],-0.55202,47.47156,{"lat":205,"lon":204},[208,212],{"name":209,"role":40,"phone":210,"phoneExt":10,"email":211},"Audrey Olivier","+33 241355615","auolivier@chu-angers.fr",{"name":213,"role":36,"phone":10,"phoneExt":10,"email":10},"Christopher Verny, Dr",{"facility":215,"status":49,"city":216,"state":10,"zip":217,"country":201,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"Le Centre Hospitalier Universitaire de Bordeaux","Bordeaux","33076",{"type":54,"coordinates":219},[220,221],-0.58046,44.84124,{"lat":221,"lon":220},[224,228],{"name":225,"role":40,"phone":226,"phoneExt":10,"email":227},"Marie-Pierre Baudier","+33 (0)149 814 301","marie-pierre.baudier@chu-bordeaux.fr",{"name":229,"role":36,"phone":10,"phoneExt":10,"email":10},"Cyril Goizet, Prof",{"facility":231,"status":49,"city":232,"state":233,"zip":234,"country":235,"cosmosGeoPoint":236,"geoPoint":240,"contacts":241},"University Hospital Ulm","Ulm","Baden-Wurttemberg","89081","Germany",{"type":54,"coordinates":237},[238,239],9.99155,48.39841,{"lat":239,"lon":238},[242,246],{"name":243,"role":40,"phone":244,"phoneExt":10,"email":245},"Olga Kuvarzina","+49 731-500-63080","Olga.Kuvarzina@uniklinik-ulm.de",{"name":247,"role":36,"phone":10,"phoneExt":10,"email":10},"Jan Lewerenz, MD",{"facility":249,"status":49,"city":250,"state":251,"zip":252,"country":235,"cosmosGeoPoint":253,"geoPoint":257,"contacts":258},"Dresden University","Dresden","Saxony","01307",{"type":54,"coordinates":254},[255,256],13.73832,51.05089,{"lat":256,"lon":255},[259,263],{"name":260,"role":40,"phone":261,"phoneExt":10,"email":262},"Stefan Bräuer","351- 458 2524","Stefan.Braeuer@ukdd.de",{"name":264,"role":36,"phone":10,"phoneExt":10,"email":10},"Bjoern Falkenburger, MD",{"facility":266,"status":49,"city":267,"state":10,"zip":268,"country":235,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"St Josef And Elisabeth Hospital","Bochum","44791",{"type":54,"coordinates":270},[271,272],7.21648,51.48165,{"lat":272,"lon":271},[275,278],{"name":276,"role":40,"phone":10,"phoneExt":10,"email":277},"Barbara Kaminski","b.kaminski@klinikum-bochum.de",{"name":279,"role":36,"phone":10,"phoneExt":10,"email":10},"Carsten Saft",{"facility":281,"status":49,"city":282,"state":10,"zip":283,"country":235,"cosmosGeoPoint":284,"geoPoint":288,"contacts":289},"University Hospital of Erlangen","Erlangen","91054",{"type":54,"coordinates":285},[286,287],11.00783,49.59099,{"lat":287,"lon":286},[290,294],{"name":291,"role":40,"phone":292,"phoneExt":10,"email":293},"Susanne Seifert","09131-85-44751","susanne.seifert@uk-erlangen.de",{"name":295,"role":36,"phone":10,"phoneExt":10,"email":10},"Winkler Jurgen",{"facility":297,"status":49,"city":298,"state":10,"zip":299,"country":235,"cosmosGeoPoint":300,"geoPoint":304,"contacts":305},"George Huntington Institute","Münster","48149",{"type":54,"coordinates":301},[302,303],7.62571,51.96236,{"lat":303,"lon":302},[306,310],{"name":307,"role":40,"phone":308,"phoneExt":10,"email":309},"Svenja Aufenberg","+49-251-788-788-0","svenja.aufenberg@ghi-muenster.de",{"name":311,"role":36,"phone":10,"phoneExt":10,"email":10},"Ralf Reilmann",{"facility":313,"status":49,"city":314,"state":10,"zip":315,"country":235,"cosmosGeoPoint":316,"geoPoint":320,"contacts":321},"Kbo-Isar-Amper-Klinikum Taufkirchen (Vils)","Taufkirchen","84416",{"type":54,"coordinates":317},[318,319],11.61701,48.0486,{"lat":319,"lon":318},[322,326],{"name":323,"role":40,"phone":324,"phoneExt":10,"email":325},"Michael Bachmaier","08084-934-417","Michael.Bachmaier@kbo.de",{"name":327,"role":36,"phone":10,"phoneExt":10,"email":10},"Alzbeta Mühlbäck, MD, PhD",{"facility":329,"status":150,"city":330,"state":10,"zip":331,"country":332,"cosmosGeoPoint":333,"geoPoint":337,"contacts":10},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","Milan","20133","Italy",{"type":54,"coordinates":334},[335,336],9.18951,45.46427,{"lat":336,"lon":335},{"facility":339,"status":49,"city":340,"state":10,"zip":341,"country":332,"cosmosGeoPoint":342,"geoPoint":346,"contacts":347},"Lega Italiana Ricera Huntington","Rome","00185",{"type":54,"coordinates":343},[344,345],12.51133,41.89193,{"lat":345,"lon":344},[348,351],{"name":349,"role":40,"phone":10,"phoneExt":10,"email":350},"Paola Mina","paola.mina@lirh.it",{"name":352,"role":36,"phone":10,"phoneExt":10,"email":10},"Ferdinando Squitieri, MD",{"facility":354,"status":49,"city":355,"state":356,"zip":357,"country":358,"cosmosGeoPoint":359,"geoPoint":363,"contacts":364},"The University of Auckland","Grafton","Auckland","1023","New Zealand",{"type":54,"coordinates":360},[361,362],174.76566,-36.86029,{"lat":362,"lon":361},[365,369],{"name":366,"role":40,"phone":367,"phoneExt":10,"email":368},"Christina Buchanan","+64 9 307 4949","CBuchanan@adhb.govt.nz",{"name":370,"role":36,"phone":10,"phoneExt":10,"email":10},"Richard Roxburgh, Prof",{"facility":372,"status":49,"city":373,"state":374,"zip":375,"country":358,"cosmosGeoPoint":376,"geoPoint":380,"contacts":381},"NZ Brain Research Institute","Christchurch","Canterbury","8011",{"type":54,"coordinates":377},[378,379],172.63333,-43.53333,{"lat":379,"lon":378},[382,385],{"name":383,"role":40,"phone":10,"phoneExt":10,"email":384},"Laura Paermentier","Laura.Paermentier@cdhb.health.nz",{"name":386,"role":36,"phone":10,"phoneExt":10,"email":10},"Tim Anderson, Prof",{"facility":388,"status":150,"city":389,"state":10,"zip":390,"country":391,"cosmosGeoPoint":392,"geoPoint":396,"contacts":10},"Institute of Psychiatry and Neurology","Warsaw","02-957","Poland",{"type":54,"coordinates":393},[394,395],21.01178,52.22977,{"lat":395,"lon":394},{"facility":398,"status":49,"city":399,"state":10,"zip":400,"country":401,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"Gulbenkian Institute of Molecular Medicine","Lisbon","1649-028","Portugal",{"type":54,"coordinates":403},[404,405],-9.1498,38.72509,{"lat":405,"lon":404},[408,412],{"name":409,"role":40,"phone":410,"phoneExt":10,"email":411},"Ines Dias","+351925865042","neurociencias.movimento@gmail.com",{"name":413,"role":36,"phone":10,"phoneExt":10,"email":10},"Leonor Correia-Guedes, MD",{"facility":415,"status":150,"city":416,"state":417,"zip":418,"country":419,"cosmosGeoPoint":420,"geoPoint":424,"contacts":10},"Cruces University Hospital","Bilbao","Biscay","48903","Spain",{"type":54,"coordinates":421},[422,423],-2.92528,43.26271,{"lat":423,"lon":422},{"facility":426,"status":49,"city":427,"state":10,"zip":428,"country":419,"cosmosGeoPoint":429,"geoPoint":433,"contacts":434},"Hospital de Sant Pau","Barcelona","08041",{"type":54,"coordinates":430},[431,432],2.15899,41.38879,{"lat":432,"lon":431},[435,440],{"name":436,"role":40,"phone":437,"phoneExt":438,"email":439},"Sofia Bonavita","+34 932919000","8533","SBonavita@santpau.cat",{"name":441,"role":36,"phone":10,"phoneExt":10,"email":10},"Jamie Kulisevsky, MD, PhD",{"facility":443,"status":49,"city":444,"state":10,"zip":445,"country":419,"cosmosGeoPoint":446,"geoPoint":450,"contacts":451},"Ramón y Cajal Universitary Hospital","Madrid","28034",{"type":54,"coordinates":447},[448,449],-3.70256,40.4165,{"lat":449,"lon":448},[452,455],{"name":453,"role":40,"phone":10,"phoneExt":10,"email":454},"Rocio Lopez Perez","rocio.lopez.externo@salud.madrid.org",{"name":456,"role":36,"phone":10,"phoneExt":10,"email":10},"Jose Louis Lopez Sendon, Dr",{"facility":458,"status":49,"city":459,"state":460,"zip":461,"country":462,"cosmosGeoPoint":463,"geoPoint":467,"contacts":468},"Royal Devon & Exeter NHS Foundation Trust","Exeter","Devon","EX2 5DW","United Kingdom",{"type":54,"coordinates":464},[465,466],-3.52751,50.7236,{"lat":466,"lon":465},[469,473],{"name":470,"role":40,"phone":471,"phoneExt":10,"email":472},"Julie Moss","01392408181","julie.moss10@nhs.net",{"name":474,"role":36,"phone":10,"phoneExt":10,"email":10},"Tim Harrower, MBBS",{"facility":476,"status":49,"city":477,"state":478,"zip":479,"country":462,"cosmosGeoPoint":480,"geoPoint":484,"contacts":485},"Glasgow Clinical Research Facility","Glasgow","Scotland","G51 4TF",{"type":54,"coordinates":481},[482,483],-4.25763,55.86515,{"lat":483,"lon":482},[486,490],{"name":487,"role":40,"phone":488,"phoneExt":10,"email":489},"Helen Bannister","0141 232 7600","helen.bannister@ggc.scot.nhs.uk",{"name":491,"role":36,"phone":10,"phoneExt":10,"email":10},"James Herron, Dr",{"facility":493,"status":49,"city":494,"state":495,"zip":496,"country":462,"cosmosGeoPoint":497,"geoPoint":501,"contacts":502},"Birmingham Huntingtons Disease Clinic","Birmingham","West Midlands","B15 2 FG",{"type":54,"coordinates":498},[499,500],-1.89983,52.48142,{"lat":500,"lon":499},[503,507],{"name":504,"role":40,"phone":505,"phoneExt":10,"email":506},"Elsa Benn","0121 301 2363","e.benn@nhs.net",{"name":508,"role":36,"phone":10,"phoneExt":10,"email":10},"Hugh Rickards, MB, ChB, MSc, FRCPsych, MD",{"facility":510,"status":150,"city":511,"state":10,"zip":512,"country":462,"cosmosGeoPoint":513,"geoPoint":517,"contacts":10},"North Bristol NHS Trust","Bristol","BS10 5NB",{"type":54,"coordinates":514},[515,516],-2.59665,51.45523,{"lat":516,"lon":515},{"facility":519,"status":49,"city":520,"state":10,"zip":521,"country":462,"cosmosGeoPoint":522,"geoPoint":526,"contacts":527},"Cambridge University Hospitals NHS Foundation Trust","Cambridge","CB2 0PY",{"type":54,"coordinates":523},[524,525],0.11667,52.2,{"lat":525,"lon":524},[528,532],{"name":529,"role":40,"phone":530,"phoneExt":10,"email":531},"Katie Andresen","01223 331141","kera2@cam.ac.uk",{"name":533,"role":36,"phone":10,"phoneExt":10,"email":10},"Roger Barker",{"facility":535,"status":49,"city":536,"state":10,"zip":537,"country":462,"cosmosGeoPoint":538,"geoPoint":542,"contacts":543},"Cardiff University","Cardiff","CF24 4HQ",{"type":54,"coordinates":539},[540,541],-3.18,51.48,{"lat":541,"lon":540},[544,548],{"name":545,"role":40,"phone":546,"phoneExt":10,"email":547},"Alison Johnson","02920746394","alison.johnson@wales.nhs.uk",{"name":549,"role":36,"phone":10,"phoneExt":10,"email":10},"Anne Rosser, MD",{"facility":551,"status":150,"city":552,"state":10,"zip":553,"country":462,"cosmosGeoPoint":554,"geoPoint":558,"contacts":10},"Fife Health Board - Whyteman's Brae Hospital","Kirkcaldy","KY1 2ND",{"type":54,"coordinates":555},[556,557],-3.15999,56.11683,{"lat":557,"lon":556},{"facility":560,"status":49,"city":561,"state":10,"zip":562,"country":462,"cosmosGeoPoint":563,"geoPoint":567,"contacts":568},"Leeds Teaching Hospital Trust","Leeds","LS7 4SA",{"type":54,"coordinates":564},[565,566],-1.54785,53.79648,{"lat":566,"lon":565},[569,573],{"name":570,"role":40,"phone":571,"phoneExt":10,"email":572},"Dominique Barker","0113 39 24679","dominique.barker@nhs.net",{"name":574,"role":36,"phone":10,"phoneExt":10,"email":10},"Jeremy Cosgrove, MBBS",{"facility":576,"status":49,"city":577,"state":10,"zip":578,"country":462,"cosmosGeoPoint":579,"geoPoint":583,"contacts":584},"The Walton Centre NHS Foundation Trust","Liverpool","L9 7LJ",{"type":54,"coordinates":580},[581,582],-2.97794,53.41058,{"lat":582,"lon":581},[585,588],{"name":586,"role":40,"phone":10,"phoneExt":10,"email":587},"Jenni Burns, BSc MSc","jenni.burns3@nhs.net",{"name":589,"role":36,"phone":10,"phoneExt":10,"email":10},"Rhys Davies, MA BM BCh PhD FRCP",{"facility":591,"status":49,"city":592,"state":10,"zip":593,"country":462,"cosmosGeoPoint":594,"geoPoint":598,"contacts":599},"University College London Hospitals NHS Foundation Trust","London","NW1 2PG",{"type":54,"coordinates":595},[596,597],-0.12574,51.50853,{"lat":597,"lon":596},[600,604],{"name":601,"role":40,"phone":602,"phoneExt":10,"email":603},"Opeyemi Kinyomi","0203 108 2638","o.kinyomi@ucl.ac.uk",{"name":605,"role":36,"phone":10,"phoneExt":10,"email":10},"Edward Wild, MD, PhD",{"facility":607,"status":49,"city":592,"state":10,"zip":608,"country":462,"cosmosGeoPoint":609,"geoPoint":611,"contacts":612},"St George's University Of London","SW17 0RE",{"type":54,"coordinates":610},[596,597],{"lat":597,"lon":596},[613,617],{"name":614,"role":40,"phone":615,"phoneExt":10,"email":616},"Hae-Ree Seo","0208 725 5375","HaeRee.Seo@stgeorges.nhs.uk",{"name":618,"role":36,"phone":10,"phoneExt":10,"email":10},"Nayana Lahiri",{"facility":620,"status":49,"city":621,"state":10,"zip":622,"country":462,"cosmosGeoPoint":623,"geoPoint":627,"contacts":628},"Oxford University Hospitals NHS Foundation Trust","Oxford","OX3 9DU",{"type":54,"coordinates":624},[625,626],-1.25596,51.75222,{"lat":626,"lon":625},[629,633],{"name":630,"role":40,"phone":631,"phoneExt":10,"email":632},"Zara Skitt","01865 234309","zara.skitt@ouh.nhs.uk",{"name":634,"role":36,"phone":10,"phoneExt":10,"email":10},"Richard Armstrong, MA, PhD, BMBCh, MRCP",{"facility":636,"status":49,"city":637,"state":10,"zip":638,"country":462,"cosmosGeoPoint":639,"geoPoint":643,"contacts":644},"University Hospitals Plymouth NHS Trust","Plymouth","PL6 5FP",{"type":54,"coordinates":640},[641,642],-4.14305,50.37153,{"lat":642,"lon":641},[645,649],{"name":646,"role":40,"phone":647,"phoneExt":10,"email":648},"Elizabeth Cray","01752 439636","elizabethcray@nhs.net",{"name":650,"role":36,"phone":10,"phoneExt":10,"email":10},"Daniel Lashley, MBBS",{"type":36,"investigatorFullName":652,"investigatorTitle":653,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Edward Wild","Dr",[655],{"name":656,"class":6},"CHDI Foundation, Inc.","100274686",false,"NCT02855476","HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease","HDClarity","Inclusion Criteria:\n\n* Age (18-75 years controls, early\u002Flate premanifest HD and incomplete penetrance HD, 21-75 years early\u002Fmoderate\u002Fadvanced manifest HD, ≥11 years juvenile HD)\n* Enroll HD participant\n* Capable of consenting or have a legal representative (parent\u002Fguardian for juveniles)\n* Capable of complying with study procedures\n* All participants other than family and community controls must have had a genetic test for HD\n\nExclusion Criteria:\n\n* Drug trial within 30 days of any sampling visit\n* Changes in medication (antidepressant, psychoactive, psychotropic or other medications or nutraceuticals used to treat HD within 30 days)\n* Antiplatelet or anticoagulant therapy within 14 days\n* Significant comorbidity\n* Needle phobia, headache, spinal surgery \u002F deformity\n* Clotting or bruising disorder\n* Screening blood test abnormalities \\>10% outside normal range\n* Drug \u002F alcohol abuse\n* Positive urine pregnancy test at any screening or sampling visit for females of childbearing potential\n* Predictable non compliance or unwillingness\n* Serious adverse event related to HDClarity study procedures or any lumbar puncture procedure performed for any reason in the previous 30 days",true,"ALL","11 Years","75 Years",{"count":668,"type":669},2500,"ESTIMATED","OBSERVATIONAL","HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.",[673],"Huntington's Disease","2026-04-24",{"date":676,"type":677},"2026-04-27","ACTUAL",{"date":679,"type":677},"2017-01-01",{"name":5,"class":6},40]