[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614390":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":129,"collaborators":24,"id":132,"slug":24,"hasResults":133,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":133,"sex":139,"minAge":140,"maxAge":24,"enrollmentInfo":141,"targetDuration":24,"studyType":144,"phases":145,"briefSummary":147,"conditions":148,"keywords":153,"overallStatus":46,"whyStopped":24,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":167},{"fullName":5,"class":6},"AUB Santé","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequence 1: HD HDF","EXPERIMENTAL","The patient will receive three months of HD followed by three months of HDF",[13,14],"Other: High-flux hemodialysis","Other: Hemodiafiltration",{"label":16,"type":10,"description":17,"interventionNames":18},"Sequence 2: HDF HD","The patient will receive three months of HDF followed by three months of HD",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"High-flux hemodialysis","High-flux hemodialysis removes small and middle molecular solutes through the mechanism of diffusion.",[9,16],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Hemodiafiltration","Hemodiafiltration removes solutes using convection which allows for more epuration of middle molecular solutes.",[9,16],[30],{"name":31,"affiliation":32,"role":33},"Mabel Aoun, M.D., M.P.H.","AUB SANTE","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Mabel AOUN, M.D., M.P.H.","CONTACT","+33174743551","aounmabel@yahoo.fr",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},"Sibylle Gourvil","02.90.22.64.05","sibylle.gourvil@aub-sante.fr",[45,72,89,110],{"facility":5,"status":46,"city":47,"state":24,"zip":24,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Bretagne","France",{"type":50,"coordinates":51},"Point",[52,53],6.9977,47.59535,{"lat":53,"lon":52},[56,60,63,65,68,70],{"name":57,"role":37,"phone":58,"phoneExt":24,"email":59},"Thibault DOLLEY-HITZE, M.D.","+33299200140","thibault.dolley-hitze@aub-sante.fr",{"name":61,"role":37,"phone":24,"phoneExt":24,"email":62},"Simon DUQUENNOY, M.D.","simon.duquennoy@aub-sante.fr",{"name":57,"role":64,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"name":66,"role":67,"phone":24,"phoneExt":24,"email":24},"Eric LARUELLE, M.D.","SUB_INVESTIGATOR",{"name":69,"role":67,"phone":24,"phoneExt":24,"email":24},"Morgane GOSSELIN, M.D.",{"name":71,"role":67,"phone":24,"phoneExt":24,"email":24},"Bruno LEGENDRE, M.D.",{"facility":73,"status":46,"city":74,"state":24,"zip":75,"country":48,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"AIDER","Grabels","34790",{"type":50,"coordinates":77},[78,79],3.80144,43.648,{"lat":79,"lon":78},[82,85,88],{"name":83,"role":37,"phone":24,"phoneExt":24,"email":84},"Annie RODRIGUEZ","a.rodriguez@aidersante.com",{"name":86,"role":37,"phone":24,"phoneExt":24,"email":87},"Anne WUILLAI, M.D.","a.wuillai@aidersante.com",{"name":86,"role":64,"phone":24,"phoneExt":24,"email":24},{"facility":90,"status":46,"city":91,"state":24,"zip":24,"country":48,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"ECHO","Le Mans",{"type":50,"coordinates":93},[94,95],0.20251,48.0021,{"lat":95,"lon":94},[98,102,104,105,106,108],{"name":99,"role":37,"phone":100,"phoneExt":24,"email":101},"Guillaume SERET, M.D.","+33243432474","gseret@echo-sante.com",{"name":103,"role":37,"phone":24,"phoneExt":24,"email":24},"Frédéric LAVAINNE, M.D.",{"name":99,"role":64,"phone":24,"phoneExt":24,"email":24},{"name":103,"role":67,"phone":24,"phoneExt":24,"email":24},{"name":107,"role":67,"phone":24,"phoneExt":24,"email":24},"Lurlings GENDROT, M.D.",{"name":109,"role":67,"phone":24,"phoneExt":24,"email":24},"Wael AL HAGGAN, M.D.",{"facility":111,"status":46,"city":112,"state":24,"zip":24,"country":48,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Aura Paris","Paris",{"type":50,"coordinates":114},[115,116],2.3488,48.85341,{"lat":116,"lon":115},[119,123,125,126,127],{"name":120,"role":37,"phone":121,"phoneExt":24,"email":122},"Pablo URENA, M.D.","+33149189393","pablo.urena@auraparis.org",{"name":124,"role":37,"phone":24,"phoneExt":24,"email":24},"Rime OSSMANE, M.D.",{"name":120,"role":64,"phone":24,"phoneExt":24,"email":24},{"name":124,"role":67,"phone":24,"phoneExt":24,"email":24},{"name":128,"role":67,"phone":24,"phoneExt":24,"email":24},"Minh Hoang TRAN, M.D.",{"type":64,"investigatorFullName":130,"investigatorTitle":131,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Mabel Aoun","Nephrologist","100614390",false,"NCT07278973","Hemodiafiltration Versus Hemodialysis in Older People","HemoDiafiltration Versus HemoDialysis in OLDER People: a Randomized, Multicenter, Crossover, Pragmatic Clinical Trial","HD-OLDER","Inclusion Criteria:\n\n* Signed and dated informed consent\n* Age \\>84 years\n* Diagnosed with kidney failure\n* On maintenance hemodialysis \\>3months\n* Willing to have a dialysis session of 3.5 to 4-hour duration, three times a week\n* Has a reliable vascular access\n* Is covered by the health insurance\n\nExclusion Criteria:\n\n* Patients with cognitive impairment (assessed with a mini-test if needed)\n* Hospitalized at inclusion\n* Have difficulties with French speaking\n* Terminally ill with life expectancy\\\u003C3 months\n* With active cancer","ALL","85 Years",{"count":142,"type":143},62,"ESTIMATED","INTERVENTIONAL",[146],"NA","This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF).\n\nPatients will receive the treatment over two periods: if period 1 is HD then period 2 will be HDF. Every patient will be his\u002Fher own control, this is why it is called cross-over. Each period will last three months. Between the two periods, patients will receive a traditional low-flux hemodialysis.\n\nThese two techniques are widely used worldwide and their side-effects are well-known and do not put the patients at risk. HDF has been shown to improve survival in patients with a mean age of 58 years. But a previous study from the investigators' group showed that HDF causes a prolonged recovery time in older patients. This randomized trial aims to elucidate this question.",[149,26,150,151,152],"Hemodialysis","Fatigue Symptom","Quality of Life of Patients","Older People",[149,26,154,155,156,157],"Older people","Fatigue","Patient reported outcome","Dialysis recovery time","2026-02-20",{"date":160,"type":161},"2026-02-23","ACTUAL",{"date":163,"type":143},"2026-02-19",{"date":165,"type":143},"2026-12-19",{"name":5,"class":6},4]