[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100202604":3},{"organization":4,"outcomesModule":7,"designInfo":22,"detailedDescription":26,"studyPopulation":27,"armGroups":28,"interventions":23,"overallOfficials":32,"centralContacts":37,"locations":46,"responsibleParty":77,"collaborators":23,"id":80,"slug":23,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":23,"studyType":93,"phases":23,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":49,"whyStopped":23,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Ulm","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"responsiveness to recombinant human granulocyte colony-stimulating factor (rhG-CSF)","increase in leukocytes","within 7 days",[14],{"measure":15,"description":16,"timeFrame":17},"8 clinical HLH criteria","degree of fulfillment x out of 8 clinical HLH criteria","7 days",[19],{"measure":20,"description":21,"timeFrame":17},"differential blood count, enzymes,biomarkers,immunophenotype","Differential blood count, lactate dehydrogenase, C reactive protein, fibrinogen, triglycerides, ferritin,liver enzymes, aspartate aminotransferase, soluble cluster of differentiation 25, cytokines, procalcitonin biomarkers,immunophenotype (flow cytometry)",{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":24,"timePerspective":25,"maskingInfo":23},null,"CASE_ONLY","PROSPECTIVE","In children with bi- or pancytopenia, hemophagocytosis is known as life-threatening hemophagocytic lymphohistiocytosis (HLH). The purpose of the study is to find out whether adult patients with bicytopenia or pancytopenia fulfilling the clinical HLH criteria used in children reflect life-threatening hemophagocytosis and whether hemophagocytosis is associated with responsiveness to recombinant human granulocyte colony-stimulation factor (rhG-CSF) or not.","Patients with leukopenia who are routinely treated with rhG-CSF",[29],{"label":30,"type":23,"description":31,"interventionNames":23},"patients with cytopenias","Patients with sepsis and concomitant cytopenias (leukopenia with thrombocytopenia and anemia) who are routinely treated with rhG-CSF will be followed for reconstitution of peripheral blood cell counts. In cooperation with the Department of Hematology, patients are examined for bone marrow cellularity and hemophagocytosis if G-CSF treatment does not result in leukocyte increase.",[33],{"name":34,"affiliation":35,"role":36},"Manfred E Weiss, MD","Department of Anesthesiology","PRINCIPAL_INVESTIGATOR",[38,42],{"name":34,"role":39,"phone":40,"phoneExt":23,"email":41},"CONTACT","49-731-50060226","manfred.weiss@uniklinik-ulm.de",{"name":43,"role":39,"phone":44,"phoneExt":23,"email":45},"Elisabeth M Schneider, PhD","49-731-50060080","marion.schneider@uni-ulm.de",[47,65],{"facility":48,"status":49,"city":50,"state":23,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Department of Anaesthesiology, University Hospital Ulm","RECRUITING","Ulm","89075","Germany","DE",{"type":55,"coordinates":56},"Point",[57,58],9.99155,48.39841,{"lat":58,"lon":57},[61,63],{"name":34,"role":39,"phone":62,"phoneExt":23,"email":41},"49 (0)731-500-60226",{"name":43,"role":39,"phone":64,"phoneExt":23,"email":45},"49 (0)731-500-60319",{"facility":66,"status":49,"city":50,"state":23,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},"Department of Internal Medicine III, Comprehensive Infectious Disease Center, University Hospital Ulm, Germany",{"type":55,"coordinates":68},[57,58],{"lat":58,"lon":57},[71,75],{"name":72,"role":39,"phone":73,"phoneExt":23,"email":74},"Martin Bommer, MD","+49 (731) 500-45530","Martin.Bommer@uniklinik-ulm.de",{"name":43,"role":39,"phone":76,"phoneExt":23,"email":45},"+49 (731) 500-60080",{"type":36,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Manfred Weiss","Professor, MD, MBA","100202604",false,"NCT01913938","Hemophagocytosis in Critically Ill Adult Patients","Hemophagocytosis in Critically Ill Adult Patients With Cytopenias","HCIAP","Inclusion Criteria:\n\n* age \\> 18 years\n* critically ill adult patients\n* leukopenia and thrombocytopenia\n* rhG-CSF therapy\n\nExclusion Criteria:\n\n* life expectancy \\\u003C 24 hours\n* inclusion in other studies\n* trauma patients with reanimation on scene or immediately dying on hospital admission\n* pregnancy\n* hematologic disorder, malignancy\n* high dose corticosteroid treatment or chemotherapy","ALL","18 Years","90 Years",{"count":91,"type":92},40,"ESTIMATED","OBSERVATIONAL","The purpose of the study is to find out whether non-responsiveness to therapeutic recombinant human granulocyte colony-stimulation factor (rhG-CSF) is associated with hemophagocytosis in critically ill adult patients with cytopenias.",[96],"Hemophagocytosis",[98],"Hemophagocytosis, adults, rhG-CSF","2024-01-16",{"date":101,"type":102},"2024-01-17","ACTUAL",{"date":104,"type":23},"2013-07",{"date":106,"type":92},"2026-12",{"name":5,"class":6},2]