[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100432223":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":18,"responsibleParty":53,"collaborators":56,"id":59,"slug":7,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":7,"eligibilityCriteria":63,"healthyVolunteers":60,"sex":64,"minAge":7,"maxAge":7,"enrollmentInfo":65,"targetDuration":7,"studyType":68,"phases":7,"briefSummary":69,"conditions":70,"keywords":81,"overallStatus":40,"whyStopped":7,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Baylor College of Medicine","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Lindsay Burrage, MD, PhD","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Saima Ali, MSN","CONTACT","832-822-4183","saima.ali@bcm.edu",[19,39],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Children's National Medical Center","NOT_YET_RECRUITING","Washington D.C.","District of Columbia","20010","United States",{"type":27,"coordinates":28},"Point",[29,30],-77.03637,38.89511,{"lat":30,"lon":29},[33,37],{"name":34,"role":15,"phone":35,"phoneExt":7,"email":36},"Kara Simpson, MS, CGC","202-476-6216","ksimpson@childrensnational.org",{"name":38,"role":11,"phone":7,"phoneExt":7,"email":7},"Nicholas A Mew, MD",{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":25,"cosmosGeoPoint":44,"geoPoint":48,"contacts":49},"RECRUITING","Houston","Texas","77030",{"type":27,"coordinates":45},[46,47],-95.36327,29.76328,{"lat":47,"lon":46},[50,52],{"name":51,"role":15,"phone":16,"phoneExt":7,"email":17},"Saima Ali",{"name":10,"role":11,"phone":7,"phoneExt":7,"email":7},{"type":11,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Lindsay Burrage","Principal Investigator",[57],{"name":58,"class":6},"Children's National Research Institute","100432223",false,"NCT04908319","Hepatic Histopathology in Urea Cycle Disorders","Inclusion Criteria:\n\n* Diagnosis of primary urea cycle disorder based on clinical suspicion confirmed by enzyme activity, DNA testing or metabolite analysis.\n* History of liver transplantation and\u002For liver biopsy OR\n* Planned liver transplantation and\u002For liver biopsy\n\nExclusion Criteria:\n\n* Unavailability of histopathology report from the liver biopsy or explant, or unavailability of liver tissue or slides from the biopsy or explant OR\n* Anticipated inability to obtain pathology report, liver disease, tissue blocks, or pathology slides after liver biopsy or transplantation\n* Known history of a secondary cause for liver disease such as chronic viral hepatitis, autoimmune liver disease, short gut, small bowel syndrome, alcohol liver disease, or TPN-related cholestatic disease","ALL",{"count":66,"type":67},70,"ESTIMATED","OBSERVATIONAL","This is a multi-site, retrospective chart review as well as a prospective study to evaluate histopathologic findings in liver samples from individuals with any UCD diagnosis. This study will be conducted at all Urea Cycle Disorders Consortium (UCDC) sites: Baylor College of Medicine in Houston, TX and Children's National Medical Center in Washington D.C.",[71,72,73,74,75,76,77,78,79,80],"Urea Cycle Disorder","Ornithine Transcarbamylase Deficiency","Citrullinemia 1","ARGI Deficiency","ASL Deficiency","Argininosuccinic Aciduria","ASS Deficiency","Hyperargininemia","Carbamyl Phosphate Synthetase Deficiency","NAGS Deficiency",[82,83,84,85],"Liver transplant","Liver disease","Liver biopsy","Histopathology","2025-07-17",{"date":88,"type":89},"2025-07-20","ACTUAL",{"date":91,"type":89},"2022-02-24",{"date":93,"type":67},"2026-06-30",{"name":5,"class":6},2]