Health Trials

About this trial

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows:

* Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

Eligibility criteria

Qualifiers

Biological sex: female

BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2

Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)

Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).

Disqualifiers

Biological sex: male

BMI < 19 kg/m2 or > 40 kg/m2

Currently pregnant, < 2 years postpartum, lactating

Currently taking any herbal, fiber, or prebiotic supplement

Trial design

Treatments tested in this trial

  • Aerobic Exercise

Treatment groups

40 Participants
are divided into 1 treatment group

Locations

1
Milken Institute School of Public Health, The George Washington University20037, Washington D.C.District of Columbia, United States

Sponsors and collaborators

George Washington University

Lead sponsor

Source ClinicalTrials.gov