Hybrid Ablation of Atrial Fibrillation in Heart Failure

ConditionsPersistent Atrial Fibrillation Atrial Fibrillation, Persistent Atrial Arrhythmia Atrial Fibrillation Heart Failure Left Ventricular (LV) Systolic Dysfunction

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorSt. George's Hospital, London

About this trial

A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure

Eligibility criteria

Qualifiers

Age ≥ 18 years

Persistent or Long-standing Persistent AF

Dilated left atrium (at least moderately dilated)

Suitable for either procedure

Disqualifiers

Not yet optimised from a medical or lifestyle perspective for AF or heart failure

Unable to provide written consent

Previous open-heart surgery

Active infection, oesophageal ulcer stricture or oesophageal varices

Trial design

Treatments tested in this trial

AtriCure EPi-Sense-AF Guided Coagulation System +/- Atriclip
Endocardial Catheter Ablation

Treatment groups

120 Participants

are divided into 2 treatment groups

Locations

Ashford & St Peters Hospital NHS Trust Chertsey United Kingdom

Epsom General Hospital Epsom United Kingdom

Cromwell Hospital London United Kingdom

Royal Surrey County Hospital London United Kingdom

Sponsors and collaborators

St. George's Hospital, London

Lead sponsor

Source ClinicalTrials.gov