[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644242":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":39,"responsibleParty":58,"collaborators":24,"id":61,"slug":24,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Plymouth","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Hydroponic then Conventional Spinach","EXPERIMENTAL","Participants consume a hydroponic spinach smoothie at the first visit followed by a conventional spinach smoothie at the second visit, separated by a washout period.",[13,14],"Other: Hydroponic spinach smoothie","Other: Conventional spinach smoothie",{"label":16,"type":10,"description":17,"interventionNames":18},"Conventional then Hydroponic Spinach","Participants consume a conventional spinach smoothie at the first visit followed by a hydroponic spinach smoothie at the second visit, separated by a washout period.",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Hydroponic spinach smoothie","Standardized smoothie prepared with hydroponically grown spinach, matched for volume and appearance.",[16,9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Conventional spinach smoothie","Standardized smoothie prepared with conventionally grown spinach, matched for volume and appearance.",[16,9],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Raul Bescos, PhD","CONTACT","+44 1752 587585","raul.bescos@plymouth.ac.uk",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Patricia Casas Agustench, PhD","+44 1752 588892","patricia.casas@plymouth.ac.uk",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Plymouth","Devon","PL4 6AB","United Kingdom",{"type":47,"coordinates":48},"Point",[49,50],-4.14305,50.37153,{"lat":50,"lon":49},[53,54,55,57],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},{"name":31,"role":56,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"name":36,"role":56,"phone":24,"phoneExt":24,"email":24},{"type":56,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Raul Bescos","Associate Professor of Human Nutrition and Physiology","100644242",false,"NCT07665944","Hydroponic vs Conventional Spinach Smoothies: Effects on Salivary Nitrate Bioavailability and Blood Pressure","Acute Effects of Hydroponically vs. Conventionally Grown Spinach Smoothies on Salivary Nitrate Bioavailability and Blood Pressure: A Randomized Controlled Crossover Trial","SPIN-BP-NO","Inclusion Criteria:\n\n* Adults aged 18-60 years\n* Generally healthy individuals (no diagnosed chronic disease)\n* Non-smokers and non-vapers\n* Not currently taking medications known to affect cardiovascular function or nitrate metabolism\n* Able and willing to provide informed consent\n* Willing to comply with study procedures and attend both study visits\n\nExclusion Criteria:\n\n* Presence of chronic disease (e.g., cardiovascular, metabolic, renal, or respiratory conditions)\n* Use of pacemakers or implanted medical devices\n* Pregnant or lactating individuals\n* Known allergy or intolerance to spinach\n* History of gastrointestinal disorders or pathology affecting digestion or absorption\n* Use of nitrate or nitrite supplements\n* Use of antibiotics within the past 3 weeks\n* Use of antibacterial mouthwash or oral products within the past 2 weeks\n* Current participation in another clinical trial or recent participation that may interfere with outcomes",true,"ALL","18 Years","60 Years",{"count":73,"type":74},12,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to determine whether hydroponic spinach (HS) versus conventional spinach (CS) smoothies produce differential post-consumption effects on salivary nitrate availability and blood pressure in adults.\n\nThe main questions it aims to answer are:\n\nDo hydroponic spinach (HS) and conventional spinach (CS) smoothies produce differential post-consumption salivary nitrate availability responses in adults when consumed in equal volumes? Do hydroponic spinach (HS) and conventional spinach (CS) smoothies produce differential post-consumption blood pressure responses in adults when consumed in equal volumes?\n\nParticipants will:\n\nConsume hydroponic spinach (HS) and conventional spinach (CS) smoothies on two separate study days.\n\nAttend two laboratory visits at the university, scheduled within a 1-2 week period.\n\nUndergo check-ups and study measurements during each visit (e.g., blood pressure and saliva sampling).",[80],"Adult",[82,83,84,85,86,87,88,89,90,91,92,93,94],"spinach","Hydroponic agriculture","Conventional agriculture","Dietary nitrate","Nitrite","Nitric oxide","Blood pressure","Crossover study","Randomized controlled trial","Smoothie intervention","Postprandial response","Saliva biomarkers","Nitrate bioavailability","2026-06-18",{"date":97,"type":98},"2026-06-24","ACTUAL",{"date":100,"type":98},"2026-05-22",{"date":102,"type":74},"2026-07-31",{"name":5,"class":6},1]