[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100539583":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":35,"centralContacts":39,"locations":48,"responsibleParty":141,"collaborators":10,"id":143,"slug":10,"hasResults":144,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":10,"eligibilityCriteria":148,"healthyVolunteers":144,"sex":149,"minAge":150,"maxAge":10,"enrollmentInfo":151,"targetDuration":10,"studyType":154,"phases":10,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":169},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"High Risk Pancreatic Cystic Neoplasm",null,"Participants will be diagnosed with a pancreatic cystic neoplasm deemed to be high risk and requiring surgical resection",[13,14,15],"Diagnostic Test: 89Zr-DFO-HuMab-5B1 immunoPET","Diagnostic Test: HP MRI","Combination Product: Blood assay",[17,24,28],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DIAGNOSTIC_TEST","89Zr-DFO-HuMab-5B1 immunoPET","Participants who choose to will undergo immunoPET before surgery.",[9],[23],"immunoPET",{"type":18,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"HP MRI","Participants who choose to will undergo HP MRI before surgery.",[9],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"COMBINATION_PRODUCT","Blood assay","Will be drawn within 6 weeks of surgery and annually as post operative care",[9],[34],"CA19-.9",[36],{"name":37,"affiliation":5,"role":38},"Kevin Soares, MD","PRINCIPAL_INVESTIGATOR",[40,44],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":43},"CONTACT","212-639-3195","soaresk@mskcc.org",{"name":45,"role":41,"phone":46,"phoneExt":10,"email":47},"David Kelson, MD","646-888-4179","kelsend@MSKCC.ORG",[49,64,75,86,98,109,119,129],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)","RECRUITING","Basking Ridge","New Jersey","07920","United States",{"type":57,"coordinates":58},"Point",[59,60],-74.54932,40.70621,{"lat":60,"lon":59},[63],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":65,"status":51,"city":66,"state":53,"zip":67,"country":55,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Memorial Sloan Kettering Monmouth (Limited protocol activities)","Middletown","07748",{"type":57,"coordinates":69},[70,71],-74.11709,40.39428,{"lat":71,"lon":70},[74],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":76,"status":51,"city":77,"state":53,"zip":78,"country":55,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Memorial Sloan Kettering Bergen (Limited Protocol Activities)","Montvale","07645",{"type":57,"coordinates":80},[81,82],-74.02292,41.04676,{"lat":82,"lon":81},[85],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":87,"status":51,"city":88,"state":89,"zip":90,"country":55,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity)","Commack","New York","11725",{"type":57,"coordinates":92},[93,94],-73.29289,40.84288,{"lat":94,"lon":93},[97],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":99,"status":51,"city":100,"state":89,"zip":101,"country":55,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Memorial Sloan Kettering Westchester (Limited Protocol Activities)","Harrison","10604",{"type":57,"coordinates":103},[104,105],-73.71263,40.96899,{"lat":105,"lon":104},[108],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":110,"status":51,"city":89,"state":89,"zip":111,"country":55,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Memorial Sloan Kettering Cancer Center (All protocol activites)","10065",{"type":57,"coordinates":113},[114,115],-74.00597,40.71427,{"lat":115,"lon":114},[118],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":120,"status":121,"city":89,"state":89,"zip":111,"country":55,"cosmosGeoPoint":122,"geoPoint":124,"contacts":125},"Weill Cornell Medical Center (Specimen Analysis Only)","NOT_YET_RECRUITING",{"type":57,"coordinates":123},[114,115],{"lat":115,"lon":114},[126],{"name":127,"role":41,"phone":128,"phoneExt":10,"email":10},"David Lyden, MD","212-746-6565",{"facility":130,"status":51,"city":131,"state":89,"zip":132,"country":55,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Memorial Sloan Kettering Nassau (Limited Protocol Activites)","Rockville Centre","11553",{"type":57,"coordinates":134},[135,136],-73.64124,40.65871,{"lat":136,"lon":135},[139],{"name":140,"role":41,"phone":42,"phoneExt":10,"email":10},"Kevin Soares, PhD",{"type":142,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100539583",false,"NCT06305728","Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms","Immuno-Positron Emission Tomography, Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms","Inclusion Criteria:\n\n* Men and women aged \\>18 years\n* Pancreatic cystic neoplasm deemed to be high risk and requiring surgical resection\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Pathologic evidence of pancreatic cancer\n* Pregnant or breast-feeding patients\n* Refusal or inability to tolerate scan (eg anxiety or claustrophobia)\n* Inability to lay flat or meet the standard requirements of traditional MRI\n* Hepatic function from assays obtained within 6 weeks prior to the study enrollment. For each patient, the upper limit of normal (ULN) value for a particular assay will be defined by the normal reference values of the laboratory that performed the assay\n\n  1. Bilirubin \\> 1.5 x ULN\n  2. AST\u002FALT \\> 2.5 x ULN\n  3. Albumin \\\u003C 3 g\u002FdL\n  4. GGT \\> 2.5 x ULN if Alkaline Phosphatase \\> 2.5 x ULN\n* Renal function with Creatinine \\> 1.5 x ULN or creatinine clearance \\\u003C 60 mL\u002Fmin, from assays obtained within 6 weeks prior to study enrollment\n* Cardiac: congestive heart failure with New York Heart Association (NYHA) status ≥2, poorly controlled hypertension, a history of clinically significant EKG abnormalities, or myocardial infarction within 6 months of study enrollment.","ALL","18 Years",{"count":152,"type":153},25,"ESTIMATED","OBSERVATIONAL","The purpose of this study is for researchers to find ways of detecting pancreatic ductal adenocarcinoma\u002FPDAC early to avoid the invasive procedure of surgery. The study researchers think a combination of imaging and a series of blood tests may be an effective way to detect PDAC early. In this study, researchers will look at whether a combination of the following types of imaging with blood tests can detect PDAC in pancreatic cysts:\n\n* The ImmunoPET scan (immune-positron emission tomography scan) with the imaging agent 89Zr-DFO-HuMab-5B1\n* The HP MRI scan (hyperpolarized pyruvate magnetic resonance imaging scan)",[157],"Pancreatic Cyst",[157,5,159],"23-367","2025-10-08",{"date":162,"type":163},"2025-10-09","ACTUAL",{"date":165,"type":163},"2024-03-04",{"date":167,"type":153},"2030-03-04",{"name":5,"class":6},8]