Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS)

ConditionsPolycystic Ovary Syndrome Familial Partial Lipodystrophy LMNA (LaMin Nuclear A) Related Disorders

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexFemale

Age18-45

SponsorAssistance Publique - Hôpitaux de Paris

About this trial

Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/- 5 years) and Body mass index (+/- 5kg/m2).

Eligibility criteria

Qualifiers

Women aged ≥ 18 years and < 45 years ;

Discontinuation of estrogen-progestin therapyfor at least 3 months ;

Signed informed consent ;

Social security affiliation.

Disqualifiers

- Severe renal insufficiency (GFR < 30 ml/min) ;

Hepato-cellular insufficiency (TP < 50%) ;

Taking corticosteroids or antiretrovirals ;

Menopausal women ;

Trial design

Treatments tested in this trial

Genetic analysis
Biological analysis
imaging test
Standard intervention

Treatment groups

81 Participants

are divided into 2 treatment groups

Locations

Service Endocrinologie, Hôpital St Antoine75012, Paris France

Sponsors and collaborators

Assistance Publique - Hôpitaux de Paris

Lead sponsor

Source ClinicalTrials.gov