About this trial

This research is being done to evaluate multimodality imaging, including magnetic resonance imaging-guided therapy (MRT), as a possible treatment for gynecologic cancers. The therapy takes place in the Department of Radiation Oncology at the Johns Hopkins SKCCC. The purpose of this study is to investigate the ability of MRI to successfully guide the placement of the brachytherapy applicator necessary to treat participants' gynecologic cancer. The Investigators want to see if the use of MRI will do a better job of assessing the tumor at the time of brachytherapy than the routinely used CT scan. The Investigators also want to determine if the use of MRI will enable doctors to reduce the radiation dose received by the body during the process of treating the tumor.

Eligibility criteria

Qualifiers

Participants must have histologically or cytologically confirmed carcinoma. Central pathology review is not required; however, pathology will be reviewed at the SKCCC at Johns Hopkins.

Site/Stage

Carcinoma of the cervix: Stage I-IVA or vaginal recurrence

Carcinoma of the uterus: Stage IIIB (vaginal involvement), inoperable, or vaginal recurrence

Disqualifiers

Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Absolute neutrophil count < 500 at the time of enrollment

A history of metal in the head or eyes

Trial design

Treatments tested in this trial

  • Image-Guided Brachytherapy

Treatment groups

54 Participants
are divided into 1 treatment group

Locations

1
The SKCCC at Johns Hopkins21287, BaltimoreMaryland, United States

Sponsors and collaborators

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Lead sponsor

National Cancer Institute (NCI)

Collaborator