Analysis of tumor tissue (which is already available in pathology) and collection of saliva/stool and blood samples, which are obtained as part of a routine collection. These will be evaluated together with the patients' clinical data to identify possible predictors for treatment feasibility, survival, tumor control and potentially increased tumor immunogenicity by docetaxel.
Patients with squamous cell carcinomas of the oropharynx, larynx and oral cavity for whom definitive or postoperative chemoradiation is indicated
ECOG 2
Organ dysfunction ≥ 2 according to National Cancer Institute Common Toxicity Criteria (NCI CTC) Version 4.0, such as hearing loss or tinnitus or neurological diseases
Calculated creatinine clearance of ≤50ml/min
Distant metastases at the time of diagnosis and simultaneous second cancers, i.e. at the time of study inclusion
Malignancies in the last 5 years regardless of location (except basal cell carcinoma or cervical uteri)
Carcinomas in which no sample collection is possible or likely without compromising the pathological assessment
Persistent drug or medication abuse
University of Erlangen-Nürnberg Medical School
Lead sponsor