[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100394448":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":24,"studyPopulation":16,"armGroups":25,"interventions":31,"overallOfficials":37,"centralContacts":41,"locations":46,"responsibleParty":67,"collaborators":16,"id":69,"slug":16,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":16,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":16,"studyType":82,"phases":83,"briefSummary":84,"conditions":85,"keywords":16,"overallStatus":49,"whyStopped":16,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Utah","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":16},[9,13],{"measure":10,"description":11,"timeFrame":12},"Thigh Muscle Volume","change in thigh muscle volume as determined by MRI","baseline and after 2 weeks of leg immobilization",{"measure":14,"description":15,"timeFrame":12},"Leg Muscle Strength","change in isometric leg extension strength as determined by a isokinetic dynamometer",null,{"allocation":18,"interventionModel":19,"interventionModelDescription":20,"primaryPurpose":21,"observationalModel":16,"timePerspective":16,"maskingInfo":22},"NA","SINGLE_GROUP","Participants will be tested before a 2-week limb immobilization period","BASIC_SCIENCE",{"masking":23,"maskingDescription":16,"whoMasked":16},"NONE","Visit 1 (Pre-testing)- After signing a consent form, participants will undergo a blood screening and an oral glucose tolerance test. After the visit, participants will be provided with a step activity monitor to track their level of activity. A dietary assessment will also be determined.\n\nVisit 2- At a later time, the participant will return to the research center for a biopsy, blood draw, body composition scan, MRI and muscle strength testing.\n\n2-week leg immobilization period- After visit 2 , the participant will return home and undergo a 14-day leg immobilization period using the equipment and instructions provided at visit 2.\n\nVisit 3- During the limb immobilization period, participant will return to the research center for a single blood draw.\n\nVisit 4- At the end of the 2-week limb immobilization period, the participant will return to the research center to undergo another biopsy, blood draw, body composition scan, MRI and muscle strength testing.\n\nVisit 5- 2 days after the 2-week limb immobilization period, the participant will return for a biopsy and blood draw.\n\nVisit 6- 7 days after the 2-week limb immobilization period, the participant will be asked to return for a final biopsy, blood draw, body composition scan, MRI and muscle strength testing.",[26],{"label":27,"type":6,"description":28,"interventionNames":29},"Limb immobilization","Participants will undergo a 2-week leg immobilization period",[30],"Other: Limb immobilization",[32],{"type":6,"name":27,"description":33,"armGroupLabels":34,"otherNames":35},"Participants will undergo a 2-week period of leg immobilization",[27],[36],"Muscle Disuse",[38],{"name":39,"affiliation":5,"role":40},"Micah Drummond, PhD","PRINCIPAL_INVESTIGATOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":16,"email":45},"CONTACT","801-213-2737","micah.drummond@hsc.utah.edu",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"The University of Utah","RECRUITING","Salt Lake City","Utah","84112","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-111.89105,40.76078,{"lat":59,"lon":58},[62,64,65],{"name":39,"role":43,"phone":63,"phoneExt":16,"email":16},"8015877764",{"name":16,"role":43,"phone":16,"phoneExt":16,"email":45},{"name":66,"role":40,"phone":16,"phoneExt":16,"email":16},"Micah Drummond",{"type":40,"investigatorFullName":66,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"Associate Professor","100394448",false,"NCT04416191","Immune Cells During Disuse and Recovery","Muscle Immune Cells During Disuse and Recovery in Aging and Metabolic Disease","Inclusion Criteria:\n\n1. Age between 18-35 and 60-85 yrs\n2. Ability to sign informed consent\n3. Free-living, prior to admission\n\nExclusion Criteria:\n\n* History of cardiovascular disease (e.g., CHF, CAD, right-to-left shunt)\n* History of endocrine or metabolic disease such as hypo\u002Fhyperthyroidism and diabetes\n* History of kidney disease or failure\n* Vascular disease\n* Risk of DVT including family history of thrombophilia, DVT, pulmonary emboli, myeloproliferative diseases including polycythemia (Hb\\>18 g\u002FdL) or thrombocytosis (platelets\\>400x103\u002FmL), and connective tissue diseases (positive lupus anticoagulant), hyperhomocystinemia, deficiencies of factor V Leiden, proteins S and C, and antithrombine III\n* Use of anticoagulant therapy (e.g., Coumadin, heparin)\n* Elevated systolic pressure \\>150 or a diastolic blood pressure \\> 100\n* Implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators)\n* Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma\n* Currently on a weight-loss diet\n* Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular\u002Ftopical\u002Finhaled therapeutic or physiologic doses of corticosteroids are permitted)\n* Androgens or growth hormone within 6 months of enrollment and for study duration (topical physiologic androgen replacement is permitted)\n* History of stroke with motor disability\n* A recent history (\\\u003C12 months) of GI bleed\n* History of liver disease\n* History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)\n* Pregnancy as determined by a pregnancy test\n* Any staff members who report directly to an investigator or who report to someone who reports directly to an investigator.\n* Any other condition or event considered exclusionary by the PI and faculty physician",true,"ALL","18 Years","85 Years",{"count":80,"type":81},45,"ESTIMATED","INTERVENTIONAL",[18],"This is an interventional study enrolling healthy individuals aged 18-35 and 60-85 to understand the recovery of muscle health following a period of inactivity. The enrollment goal is 45 participants. The study will occur over the course of 1-2 months where participants will undergo testing before and after a 2-week limb immobilization period.",[36],"2025-12-01",{"date":88,"type":89},"2025-12-05","ACTUAL",{"date":91,"type":89},"2022-05-15",{"date":93,"type":81},"2028-04-30",{"name":5,"class":6},1]